Zebrafish sex: a complicated affair.
Zebrafish sex: a complicated affair.
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DOI：
10.1093/bfgp/elt041
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发表时间：
2014-03
影响因子：
4
通讯作者：
Orbán L
中科院分区：
文献类型：
--
作者：
Liew WC;Orbán L
本文就斑马鱼性别决定和性腺分化机制的研究进展作一综述。我们表明，从大多数研究中获得的数据是兼容的多基因性别决定（PSD），其中的决定是由几个位点的等位基因组合。这些位点通常分散在整个基因组中，但在某些硬骨鱼物种中，其中一些可能位于一对优先的（性）染色体上。PSD系统在配子水平和个体性别基因型水平上的SD基因型变异水平均远高于染色体性别决定系统。雄性斑马鱼的早期性发育是一个复杂的过程，因为它们首先发育出一个“幼年卵巢”，随后经历了一个转变，让位于睾丸。迄今为止，三个主要的发育途径被证明是通过调节程序性细胞死亡参与性腺分化。我们认为，有更多的途径参与调控斑马鱼性腺分化/转化。在斑马鱼繁殖分析中引入其他强大的大规模基因组方法将进一步加深我们的知识，并在不久的将来确定与这些过程相关的其他途径和基因。
In this review, we provide a detailed overview of studies on the elusive sex determination (SD) and gonad differentiation mechanisms of zebrafish (Danio rerio). We show that the data obtained from most studies are compatible with polygenic sex determination (PSD), where the decision is made by the allelic combinations of several loci. These loci are typically dispersed throughout the genome, but in some teleost species a few of them might be located on a preferential pair of (sex) chromosomes. The PSD system has a much higher level of variation of SD genotypes both at the level of gametes and the sexual genotype of individuals, than that of the chromosomal sex determination systems. The early sexual development of zebrafish males is a complicated process, as they first develop a ‘juvenile ovary’, that later undergoes a transformation to give way to a testis. To date, three major developmental pathways were shown to be involved with gonad differentiation through the modulation of programmed cell death. In our opinion, there are more pathways participating in the regulation of zebrafish gonad differentiation/transformation. Introduction of additional powerful large-scale genomic approaches into the analysis of zebrafish reproduction will result in further deepening of our knowledge as well as identification of additional pathways and genes associated with these processes in the near future.
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影响因子：
2.7
作者：
Dranow, Daniel B.;Tucker, Richard P.;Draper, Bruce W.
通讯作者：
Draper, Bruce W.
影响因子：
2.9
作者：
Chang, Alex;Liew, Woei Chang;Orban, Laszlo
通讯作者：
Orban, Laszlo
DOI：
10.1016/s1532-0456(01)00267-8
发表时间：
2001-12-01
影响因子：
3.9
作者：
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通讯作者：
D'Cotta, H
影响因子：
2.3
作者：
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通讯作者：
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DOI：
10.1016/j.biocel.2009.07.001
发表时间：
2010-03-01
影响因子：
4
作者：
Bagheri-Fam, Stefan;Sinclair, Andrew H.;Harley, Vincent R.
通讯作者：
Harley, Vincent R.