Structure of the human interleukin-2 receptor gene.
Structure of the human interleukin-2 receptor gene.
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人类白介素 2 受体基因的结构。
作者：
W. Leonard;J. Depper;M. Kanehisa;M. Krönke;N. Peffer;P. Svetlik;M. Sullivan;W. Greene
人白细胞介素2(IL-2)受体基因由8个外显子组成，位于10号染色体上，大小超过25kb。外显子2和4来自基因复制事件，出人意料地也与人补体因子B的识别结构域同源。替代信使RNA(MRNA)剪接可能会删除外显子4序列，导致不编码功能上的IL-2受体的mRNA。感染HTLV-I的白血病T细胞和正常活化的T细胞表达IL-2受体，其推导的蛋白序列相同。在正常激活的T细胞中，受体基因的转录在两个主要位置启动。感染HTLV-I的成人T细胞白血病细胞在这两个位点都表现出活性，但也在第三个转录起始点表现出活性。
The gene encoding the human interleukin-2 (IL-2) receptor consists of 8 exons spanning more than 25 kilobases on chromosome 10. Exons 2 and 4 were derived from a gene duplication event and unexpectedly also are homologous to the recognition domain of human complement factor B. Alternative messenger RNA (mRNA) splicing may delete exon 4 sequences, resulting in a mRNA that does not encode a functional IL-2 receptor. Leukemic T cells infected with HTLV-I and normal activated T cells express IL-2 receptors with identical deduced protein sequences. Receptor gene transcription is initiated at two principal sites in normal activated T cells. Adult T cell leukemia cells infected with HTLV-I show activity at both of these sites, but also at a third transcription initiation site.
佛波二酯诱导人白细胞介素 2 受体的表达和磷酸化。
DOI：
--
发表时间：
1984
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Shackelford,DA;Trowbridge,IS
通讯作者：
Trowbridge,IS
影响因子：
56.9
作者：
SUDHOF, TC;GOLDSTEIN, JL;RUSSELL, DW
通讯作者：
RUSSELL, DW
人补体因子 B 酶原的完整一级结构。
DOI：
--
发表时间：
1984
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Mole,JE;Anderson,JK;Davison,EA;Woods,DE
通讯作者：
Woods,DE