Replication of genome wide association studies on hepatocellular carcinoma susceptibility loci in a Chinese population.
Replication of genome wide association studies on hepatocellular carcinoma susceptibility loci in a Chinese population.
复制标题
DOI：
10.1371/journal.pone.0077315
复制
发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Liu Y
中科院分区：
文献类型：
--
作者：
Chen K;Shi W;Xin Z;Wang H;Zhu X;Wu X;Li Z;Li H;Liu Y
全基因组关联研究（GWAS）已经鉴定出三个位点（KIF1B中的rs17401966， STAT4中的rs7574865， HLA-DQ中的rs9275319）在中国人群中与乙肝病毒相关的肝细胞癌（hbv相关的HCC）相关，两个位点（MICA中的rs2596542，位于HLA-DQA和HLA-DQB之间的rs9275572）在日本人群中与丙型肝炎病毒相关的HCC （hcv相关的HCC）相关。在本研究中，我们试图确定这些snp是否也能预测其他中国人群中hbv相关HCC的发展。采用TaqMan方法对506例hbv相关HCC患者和772例慢性乙型肝炎（CHB）患者的4个snp进行基因分型，rs2596542、rs9275572、rs17401966、rs7574865。采用logistic回归计算优势比（OR）和95%置信区间（CI）。在我们的病例对照研究中，观察到rs9275572与HCC有显著相关性（P = 0.02, OR = 0.73, 95% CI = 0.56-0.95）。在rs2596542位点6p21.33和rs9275572位点6p21.3的进一步单倍型分析中，G-A显示出对hbv相关HCC发生的保护作用（P<0.001, OR = 0.66, 95% CI = 0.52-0.84）。这些发现为rs9275572与hbv相关性HCC显著相关提供了令人信服的证据。
Genome-wide association studies (GWAS) have identified three loci (rs17401966 in KIF1B, rs7574865 in STAT4, rs9275319 in HLA-DQ) as being associated with hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC) in a Chinese population, two loci (rs2596542 in MICA, rs9275572 located between HLA-DQA and HLA-DQB) with hepatitis C virus-related HCC (HCV-related HCC) in a Japanese population. In the present study, we sought to determine whether these SNPs are predictive for HBV-related HCC development in other Chinese population as well. We genotyped 4 SNPs, rs2596542, rs9275572, rs17401966, rs7574865, in 506 HBV-related HCC patients and 772 chronic hepatitis B (CHB) patients in Han Chinese by TaqMan methods. Odds ratio(OR)and 95% confidence interval (CI) were calculated by logistic regression. In our case-control study, significant association between rs9275572 and HCC were observed (P = 0.02, OR = 0.73, 95% CI = 0.56–0.95). In the further haplotype analysis between rs2596542 at 6p21.33 and rs9275572 at 6p21.3, G-A showed a protective effect on HBV-related HCC occurrence (P<0.001, OR = 0.66, 95% CI = 0.52–0.84). These findings provided convincing evidence that rs9275572 significantly associated with HBV-related HCC.
登录
查看更多内容
影响因子：
44.1
作者：
Shi, YY;He, L
通讯作者：
He, L
影响因子：
13.5
作者：
Kong, Sun-Young;Park, Joong-Won;Mm, Chang-Min
通讯作者：
Mm, Chang-Min
影响因子：
5.8
作者：
Sole, Xavier;Guino, Elisabet;Moreno, Vitor
通讯作者：
Moreno, Vitor
CXCL10基因启动子调控多态性与男性乙型肝炎病毒携带者疾病进展
影响因子：
29.4
作者：
Deng, Guohong;Zhou, Gangqa;He, Fuchu
通讯作者：
He, Fuchu
影响因子：
30.8
作者：
Kumar, Vinod;Kato, Naoya;Matsuda, Koichi
通讯作者：
Matsuda, Koichi