The effects of long term testosterone administration on pulsatile luteinizing hormone secretion and on ovarian histology in eugonadal female to male transsexual subjects.
The effects of long term testosterone administration on pulsatile luteinizing hormone secretion and on ovarian histology in eugonadal female to male transsexual subjects.
复制标题
长期施用睾酮对性腺正常的女性到男性变性受试者的脉动黄体生成激素分泌和卵巢组织学的影响。
DOI：
10.1210/jcem-69-1-151
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Louis Gooren
中科院分区：
文献类型：
--
作者：
T. Spinder;J. Spijkstra;J. G. V. D. Tweel;C. W. Burger;H. V. Kessel;P. Hompes;Louis Gooren
多囊卵巢疾病（PCOD）与血清LH和（亚）正常FSH水平升高有关，而血清雄激素水平通常升高。为了阐明雄激素在这种促性腺激素分泌异常模式中的作用，研究了1）9名性腺正常的女性到男性变性受试者在长期（6个月）睾酮（T）给药（250 mg/2周，im）之前和期间的LH分泌，以及2）1名患有雄激素分泌性卵巢肿瘤的女性在手术切除肿瘤之前和之后的LH分泌。最后，我们研究了长期（9 - 36个月）T给药（250 mg/2周，肌肉注射）后高血清雄激素水平对卵巢组织学的影响，以评估T诱导的卵巢异常是否与PCOD女性中发生的卵巢异常相似。在9名从女性变为男性的变性受试者中，长期T治疗导致平均血清T水平从1.7 +/-0.8（+/-SD）增加到40.8 +/-31.9 nmol/L（P <0.01），平均血清双氢睾酮水平为0.6 +/-0.2至3.3 +/-1.5 nmol/L平均血清游离T水平为9.5 +/-5.2至149 +/-46 pmol/L（P <0.02）。平均血清雌酮和雌二醇水平相似之前和T治疗期间。平均血清LH水平从6.3 +/-2.0降至2.9 +/-1.1 U/L（P <0.01），平均FSH水平从6.6 +/-2.0降至3.7 +/-2.2 U/L（P <0.02）。在5名受试者中研究了T治疗前和治疗期间的脉冲式LH分泌。在这5名受试者中，LH最低值间期和LH脉冲幅度均无显著变化。患有雄激素分泌性卵巢肿瘤的女性血清T水平为9.6 nmol/L，肿瘤切除后降至正常。她的平均血清LH和FSH水平，平均最低LH间期和LH脉冲幅度在肿瘤切除前后均在正常范围内。对26名长期雄激素治疗后的变性受试者进行的卵巢组织病理学研究显示，18名受试者（69.2%）出现多个囊性卵泡，21名受试者（80.8%）出现弥漫性卵巢间质增生，25名受试者（96.2%）出现图尼卡白蛋白膜胶原化，7名受试者（26.9%）出现间质细胞黄素化。26例受试者中有18例（69.2%）的结果符合多囊卵巢病理诊断标准，即上述4项结果中的3项。（400字处截断摘要）
Polycystic ovarian disease (PCOD) is associated with elevated serum LH and (sub)normal FSH levels, while serum androgen levels are often elevated. To clarify the role of androgens in this abnormal pattern of gonadotropin secretion, LH secretion was studied in 1) 9 eugonadal female to male transsexual subjects before and during long term (6 months) testosterone (T) administration (250 mg/2 weeks, im), and 2) in a woman with an androgen-secreting ovarian tumor both before and after surgical removal of the tumor. Finally, we studied the effects of high serum androgen levels on ovarian histology in 3) 26 transsexual subjects after long term (9-36 months) T administration (250 mg/2 weeks, im) to assess whether T-induced ovarian abnormalities are similar to those that occur in women with PCOD. Long term T treatment in the nine female to male transsexual subjects resulted in increases in the mean serum T level from 1.7 +/- 0.8 (+/- SD) to 40.8 +/- 31.9 nmol/L (P less than 0.01), the mean serum dihydrotestosterone level from 0.6 +/- 0.2 to 3.3 +/- 1.5 nmol/L (P less than 0.02), and the mean serum free T level from 9.5 +/- 5.2 to 149 +/- 46 pmol/L (P less than 0.02). Mean serum estrone and estradiol levels were similar before and during T treatment. The mean serum LH level decreased from 6.3 +/- 2.0 to 2.9 +/- 1.1 U/L (P less than 0.01), and the mean FSH levels decreased from 6.6 +/- 2.0 to 3.7 +/- 2.2 U/L (P less than 0.02). Pulsatile LH secretion before and during T treatment was studied in five subjects. Neither the mean nadir LH interval nor the LH pulse amplitude changed significantly in these five subjects. The serum T level in the woman with the androgen-secreting ovarian tumor was 9.6 nmol/L, and it declined to normal after removal of the tumor. Her mean serum LH and FSH levels, the mean nadir LH interval, and LH pulse amplitude were in the normal range before and after removal of the tumor. Studies of ovarian histopathology in 26 transsexual subjects after long term androgen treatment revealed multiple cystic follicles in 18 subjects (69.2%), diffuse ovarian stromal hyperplasia in 21 subjects (80.8%), collagenization of the tunica albuginea in 25 subjects (96.2%), and luteinization of stromal cells in 7 subjects (26.9%). Findings consistent with criteria for the pathological diagnosis of polycystic ovaries, that is 3 of the 4 findings listed above, were present in 18 of the 26 subjects (69.2%).(ABSTRACT TRUNCATED AT 400 WORDS)
影响因子：
5.8
作者：
WALDSTREICHER, J;SANTORO, NF;CROWLEY, WF
通讯作者：
CROWLEY, WF