Diminished behavioral and neural sensitivity to sound modulation is associated with moderate developmental hearing loss.
Diminished behavioral and neural sensitivity to sound modulation is associated with moderate developmental hearing loss.
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DOI：
10.1371/journal.pone.0041514
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Sanes DH
中科院分区：
文献类型：
--
作者：
Rosen MJ;Sarro EC;Kelly JB;Sanes DH
声音饲养环境可以改变中央听觉编码特性，但改变神经编码很少与特定的赤字，成人的知觉技能。为了测试发育性听力损失是否导致感知和感觉编码的可比变化，我们检查了正弦幅度调制（sAM）刺激的行为和神经检测阈值。与对照组相比，双侧传导性听力损失（CHL）饲养的动物的慢（5 Hz）调制的行为sAM检测阈值显著更差。这种差异不能归因于听力阈值，熟练的任务，或代理的注意力。对于快速（100 Hz）调制，各组的检测阈值没有差异，这一结果与人类中观察到的结果相似。在来自不同清醒动物组的单个听觉皮层神经元中记录对sAM刺激的神经反应。神经测量分析表明，最敏感的神经元的阈值相当，但一个显着较差的检测阈值慢调制整个人口的CHL神经元相比，控制。神经缺陷的程度与行为差异相匹配，这表明感官信息的减少可以解释感知技能的局限性。
The acoustic rearing environment can alter central auditory coding properties, yet altered neural coding is seldom linked with specific deficits to adult perceptual skills. To test whether developmental hearing loss resulted in comparable changes to perception and sensory coding, we examined behavioral and neural detection thresholds for sinusoidally amplitude modulated (sAM) stimuli. Behavioral sAM detection thresholds for slow (5 Hz) modulations were significantly worse for animals reared with bilateral conductive hearing loss (CHL), as compared to controls. This difference could not be attributed to hearing thresholds, proficiency at the task, or proxies for attention. Detection thresholds across the groups did not differ for fast (100 Hz) modulations, a result paralleling that seen in humans. Neural responses to sAM stimuli were recorded in single auditory cortex neurons from separate groups of awake animals. Neurometric analyses indicated equivalent thresholds for the most sensitive neurons, but a significantly poorer detection threshold for slow modulations across the population of CHL neurons as compared to controls. The magnitude of the neural deficit matched that of the behavioral differences, suggesting that a reduction of sensory information can account for limitations to perceptual skills.
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影响因子：
2.8
作者：
Banai, Karen;Sabin, Andrew T.;Wright, Beverly A.
通讯作者：
Wright, Beverly A.
DOI：
10.1044/jshr.3503.642
发表时间：
1992-06-01
期刊：
JOURNAL OF SPEECH AND HEARING RESEARCH
影响因子：
--
作者：
BACON, SP;GLEITMAN, RM
通讯作者：
GLEITMAN, RM
DOI：
10.1007/s10162-010-0223-6
发表时间：
2010-12-01
影响因子：
2.4
作者：
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通讯作者：
Heinz, Michael G.
DOI：
10.1037/0097-7403.5.2.97
发表时间：
1979-01-01
期刊：
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIORAL PROCESSES
影响因子：
--
作者：
KERR, LM;OSTAPOFF, EM;RUBEL, EW
通讯作者：
RUBEL, EW
影响因子：
2.5
作者：
Beitel, Ralph E.;Vollmer, Maike;Schreiner, Christoph E.
通讯作者：
Schreiner, Christoph E.