Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.
Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.
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多阶段全基因组关联研究确定了七个前列腺癌易感位点
作者：
前列腺癌（PrCa）是发达国家最常见的男性癌症。我们对PrCa进行了多阶段全基因组关联研究，并先前报道了前两个阶段的结果，确定了16个PrCa易感位点。我们在此报告了第3阶段的结果，其中我们评估了4，574名前列腺癌患者（病例）和4，164名对照的1，536个SNP。我们通过对前列腺癌协会研究组的30项研究中的51，311个样本进行基因分型，跟踪了10个新的关联信号，以调查基因组中的癌症相关改变（PRACTICAL）联盟。除了复制先前报道的基因座外，我们还在染色体2p11、3q23、3q26、5p12、6p21、12q13和Xq12上发现了7个新的前列腺癌易感基因座（P= 4.0 × 10−8toP= 2.7 × 10−24）。我们还发现了一个SNP intTERT与PrCa的相关性比以前报道的更强。现在已经确定了40多个PrCa易感基因座，占该病家族风险的25%。
Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. We conducted a multi-stage genome-wide association study for PrCa and previously reported the results of the first two stages, which identified 16 PrCa susceptibility loci. We report here the results of stage 3, in which we evaluated 1,536 SNPs in 4,574 individuals with prostate cancer (cases) and 4,164 controls. We followed up ten new association signals through genotyping in 51,311 samples in 30 studies from the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium. In addition to replicating previously reported loci, we identified seven new prostate cancer susceptibility loci on chromosomes 2p11, 3q23, 3q26, 5p12, 6p21, 12q13 and Xq12 (P= 4.0 × 10−8toP= 2.7 × 10−24). We also identified a SNP inTERTmore strongly associated with PrCa than that previously reported. More than 40 PrCa susceptibility loci, explaining ∼25% of the familial risk in this disease, have now been identified.
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影响因子：
30.8
作者：
Marchini, Jonathan;Howie, Bryan;Donnelly, Peter
通讯作者：
Donnelly, Peter
DOI：
10.1158/1055-9965.epi-08-0342
发表时间：
2008-09
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Zuccolo L;Harris R;Gunnell D;Oliver S;Lane JA;Davis M;Donovan J;Neal D;Hamdy F;Beynon R;Savovic J;Martin RM
通讯作者：
Martin RM
影响因子：
5.3
作者：
Filion, GJP;Zhenilo, S;Defossez, PA
通讯作者：
Defossez, PA
影响因子：
4.8
作者：
Sugawara, T;Shimizu, H;Fujimoto, S
通讯作者：
Fujimoto, S
影响因子：
30.8
作者：
Eeles, Rosalind A.;Kote-Jarai, Zsofia;Easton, Douglas F.
通讯作者：
Easton, Douglas F.