Role of human metapneumovirus, influenza A virus and respiratory syncytial virus in causing WHO-defined severe pneumonia in children in a developing country.
Role of human metapneumovirus, influenza A virus and respiratory syncytial virus in causing WHO-defined severe pneumonia in children in a developing country.
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DOI：
10.1371/journal.pone.0074756
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Zaidi A
中科院分区：
文献类型：
--
作者：
Ali A;Khowaja AR;Bashir MZ;Aziz F;Mustafa S;Zaidi A
在发展中国家，呼吸道病毒在引起严重的、危及生命的肺炎中的作用还没有得到很好的确定。我们的研究旨在确定人偏肺病毒（HMPV）、甲型流感病毒和呼吸道合胞病毒（RSV）在巴基斯坦卡拉奇一家公立医院因WHO定义的重度肺炎（呼吸急促加任何一般危险体征或胸部内吸）住院的6周龄至2岁儿童中的作用。本研究于2010年11月至2011年9月在巴基斯坦卡拉奇的一家大型公立三级保健医院-Abalani Shaheed医院进行。入选了因WHO定义的重症肺炎入院的儿童，并获得咽拭子，使用真实的时间RT-PCR检测呼吸道病毒。获得所有受试者的胸部X线片，并由两名放射科医生独立解释，以诊断放射性肺炎。169名儿童被录取。重症肺炎患儿中检出HMPV 24例（14.2%），甲型流感病毒9例（5.3%），呼吸道合胞病毒30例（17.8%）。在9名甲型流感患者中，8名H1N1检测呈阳性。在18%的放射学证实的肺炎中发现了病毒病原学。HMPV感染在2月和4月达到高峰，甲型流感在1月、6月和11月流行，RSV感染在6月至9月最流行。HMPV、甲型流感和RSV是卡拉奇住院儿童中WHO定义的重症肺炎的常见病因。了解小儿肺炎的病毒病因和个体病毒季节性有助于推荐和实施适当的管理策略。
The role of respiratory viruses in causing severe, life threatening pneumonia in children in developing countries is not well established. Our study aims to determine the role of human metapneumovirus (HMPV), influenza A virus and respiratory syncytial virus (RSV) in children, aged 6 weeks to 2 years, hospitalized with WHO defined severe pneumonia (tachypnea plus any general danger sign or chest in-drawing) at a public sector hospital in Karachi, Pakistan. This study was conducted from November 2010 to September 2011 at Abbassi Shaheed Hospital, a large public tertiary care hospital in Karachi, Pakistan. Children admitted with WHO-defined severe pneumonia were enrolled and throat swabs were obtained to detect respiratory viruses using real time RT-PCR. Chest x-rays of all subjects were obtained and independently interpreted by two radiologists to diagnose radiologic pneumonia. 169 children were enrolled. HMPV was detected in 24 (14.2%), influenza A virus in 9 (5.3%) and RSV in 30 (17.8%) children admitted with severe pneumonia. Of 9 patients with influenza A, 8 tested positive for H1N1. Viral etiology was found in 18% of radiologically confirmed pneumonia. HMPV infections peaked in February and April, influenza A was prevalent in January, June and November and RSV infections were most prevalent from June to September. HMPV, influenza A and RSV are common causes of WHO-defined severe pneumonia in hospitalized children in Karachi. Knowledge regarding the viral etiology of pediatric pneumonia and individual viral seasonality can help in the recommendation and implementation of appropriate management strategies.
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DOI：
10.1016/s0140-6736(10)61459-6
发表时间：
2011-04-09
期刊：
Lancet (London, England)
影响因子：
--
作者：
Ruuskanen O;Lahti E;Jennings LC;Murdoch DR
通讯作者：
Murdoch DR
DOI：
10.2471/blt.11.098202
发表时间：
2012-10-01
期刊：
Bulletin of the World Health Organization: International Journal of Public Health
影响因子：
--
作者：
Clara, Wilfrido;Armero, Julio;Linares-Perez, Nivaldo
通讯作者：
Linares-Perez, Nivaldo
影响因子：
3.6
作者：
Brooks, W. Abdullah;Goswami, Doli;Luby, Stephen
通讯作者：
Luby, Stephen
影响因子：
3.6
作者：
Caracciolo, Sonia;Minini, Chiara;Fiorentini, Simona
通讯作者：
Fiorentini, Simona
影响因子：
3.3
作者：
Weber, MW;Mulholland, EK;Greenwood, BM
通讯作者：
Greenwood, BM