Altered functional connectivity density and structural covariance networks in women with premenstrual syndrome.
Altered functional connectivity density and structural covariance networks in women with premenstrual syndrome.
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DOI：
10.21037/qims-22-506
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发表时间：
2023-02-01
影响因子：
2.8
通讯作者：
中科院分区：
文献类型：
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作者：
经前综合征（PMS）是一种与月经有关的疾病，以身体、情绪、行为和认知症状为特征。然而，PMS的神经病理机制仍不清楚。本研究旨在探讨PMS的频率特异性功能连接密度（FCD）和结构协方差。从35名PMS患者和36名健康对照（HC）中获得功能和T1加权结构数据。本研究为横断面和前瞻性设计。计算慢4（0.027-0.073 Hz）和慢5（0.01-0.027 Hz）频段的局部/长程FCD（LFCD/LRFCD），并进行双因素方差分析（ANOVA）以确定组间的主效应以及组与频段间的交互效应。应用受试者工作特征曲线（ROC）研究PMS与HC鉴别的可靠生物标志物。根据ROC结果，描述两组纹状体各亚区全脑结构协方差模式的变化。应用相关分析研究临床症状与异常脑区之间的关系。PMS组与HC组相比，（1）扣带回中部和中央前回的功能性信息交流异常，（2）纹状体、丘脑和眶额皮层的频带交互效应显著，（3）纹状体的LFCD在ROC分析中具有更好的分类能力（slow-5），（4）纹状体的LFCD在ROC分析中具有更好的分类能力（slow-5），（5）纹状体的LFCD具有更好的分类能力（slow-5）。（IV）尾状核各亚区灰质体积减少，尾状核各亚区与额叶皮质的结构联系减少;（5）丘脑LFCD值与睡眠问题呈显著负相关（慢-5）。基于多模态磁共振成像（MRI）分析，本研究可能揭示经前综合征患者与月经周期相关的异常情绪调节和认知功能，从新的角度加深对经前综合征病理生理机制的认识。
Premenstrual syndrome (PMS) is a menstrual-related disorder, characterized by physical, emotional, behavioral and cognitive symptoms. However, the neuropathological mechanisms of PMS remain unclear. This study aimed to investigate the frequency-specific functional connectivity density (FCD) and structural covariance in PMS. Functional and T1-weighted structural data were obtained from 35 PMS patients and 36 healthy controls (HCs). This study was a cross-sectional and prospective design. The local/long-range FCD (LFCD/LRFCD) across slow-4 (0.027–0.073 Hz) and slow-5 (0.01–0.027 Hz) bands were computed, and two-way analysis of variance (ANOVA) was performed to ascertain the main effects of group and interaction effects between group and frequency band. Receiver operating characteristic (ROC) curve was performed to investigate reliable biomarkers for identifying PMS from HCs. Based on the ROC results, characterized the changes of whole-brain structural covariance patterns of striatum subregions in two groups. Correlation analysis was applied to examine relationships between the clinical symptoms and abnormal brain regions. Compared with HCs, PMS patients exhibited: (I) aberrant functional communication in the middle cingulate cortex and precentral gyrus; (II) significant frequency band-by-group interaction effects of the striatum, thalamus and orbitofrontal cortex; (III) the better classification ability of the LFCD in the striatum in ROC analysis (slow-5); (IV) decreased gray matter volumes in the caudate subregions and decreased structural associations of between the caudate subregions and frontal cortex; (V) the LFCD value in thalamus were significantly negatively correlated with the sleep problems (slow-5). Based on multi-modal magnetic resonance imaging (MRI) analysis, this study might imply the aberrant emotional regulation and cognitive function related to menstrual cycle in PMS and improve our understanding of the pathophysiologic mechanism in PMS from novel perspective.
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影响因子：
19.9
作者：
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通讯作者：
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24.5
作者：
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