Combined effects of three novel SNPs within goat LHX3 gene on milk performance
Combined effects of three novel SNPs within goat LHX3 gene on milk performance
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山羊 LHX3 基因中三个新 SNP 对产奶性能的综合影响
DOI：
10.1007/s13258-011-0026-0
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发表时间：
2011-10
期刊：
影响因子：
--
通讯作者：
Hong Chen
中科院分区：
文献类型：
--
作者：
Yao Xu;Zhuanjian Li;Chuzhao Lei;Hong Chen
In this study, single nucleotide polymorphisms (SNPs) of LHX3 gene were detected by DNA sequencing based on DNA pools and PCR-RFLP method in 792 goats belonging to three Chinese indigenous breeds (Guanzhong dairy, Xinong Sannen dairy, Inner Mongolia white cashmere). The results revealed three novel mutations (AY923832:g.7778A>T; g.8035T>C; g.10592C>T), which were named as P2-DraI, P3-HinfI and P4-MspI loci, respectively. The linkage disequilibrium analysis demonstrated P3-HinfI and P4-MspI loci were strongly linked (r2>0.33) in all the analyzed populations. Each SNP produced no significant (p>0.05) effects on milk performance. However, the two-loci and three-loci combined genotypes had more profound impacts on milk yield than in separation. The individuals with diplotype AATT (P2-DraI/P3-HinfI) showed significantly (p<0.05) higher milk yield than those with diplotypes ATTT, TTTT, ATTC, and AACC. Diplotype TTCCTT (P2-DraI/P3-HinfI/P4-MspI) carriers had significantly (p< 0.05) higher milk yield than those with diplotypes ATTTCC and AACCTC. These combined effects of LHX3 gene polymorphisms indicated that this gene had significant effect on milk performance and its corresponding combined diplotypes could be regarded as potential genetic markers of milk performance.
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影响因子：
44.1
作者：
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通讯作者：
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影响因子：
5.8
作者：
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4.8
作者：
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通讯作者：
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2.1
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通讯作者：
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