Appearance of paired nucleated, Tau-positive glia in patients with progressive supranuclear palsy brain tissue
Appearance of paired nucleated, Tau-positive glia in patients with progressive supranuclear palsy brain tissue
复制标题
进行性核上性麻痹患者脑组织中成对有核 Tau 阳性神经胶质细胞的出现
DOI：
10.1016/0304-3940(92)90145-w
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发表时间：
1992
影响因子：
2.5
通讯作者：
E. Mcgeer
中科院分区：
文献类型：
--
作者：
Tatsuo Yamada;P. Mcgeer;E. Mcgeer
在进行性核上性麻痹(PSP)患者的三个脑中发现了大量Tau阳性的胶质细胞，具有成对的核和星形细胞类型的形态。Bielschowsky‘s和Bodian’s银染及Tau-2、Alz-50、抗GFAP和抗成对螺旋丝抗体免疫染色均为阳性，而抗泛素抗体均为阴性。它们主要分布在纹状体、丘脑和额叶皮质，但在白质中未见，在神经元重度变性的区域也不丰富。电子显微镜清楚地显示了核配对，并将Tau蛋白定位于细胞质和近端突起中的微管束状物。这种神经胶质细胞在其他神经退行性疾病或神经学正常对照中很少见到。这些数据表明，在神经元丢失相对较少的脑区，PSP存在异常的胶质细胞反应。
Many Tau-positive glia with paired nuclei and astrocyte type morphology were identified in three brains from patients with progressive supranuclear palsy (PSP). They were positive by Bielschowsky's and Bodian's silver staining as well as by immunostaining with Tau-2, Alz-50, anti-GFAP and anti-paired helical filament antibodies, but not with anti-ubiquitin antibody. They were predominantly localized in the striatum, thalamus and frontal cortex but were not seen in white matter and were not plentiful in areas of heavy neuronal degeneration. Electron microscopy clearly showed the nuclear pairing and localized the Tau protein to bundles suggestive of microtubules in the cytoplasm and proximal processes. Such glial cells were rarely seen in cases of other neurodegenerative diseases or neurologically normal controls. These data suggest that there is an unusual gliotic reaction in PSP in brain areas which show relatively little neuronal loss.
区分进行性核上性麻痹和阿尔茨海默病中神经原纤维缠结的抗原决定簇的特性。
DOI：
--
发表时间：
1988
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
Schmidt,ML;Lee,VM;Hurtig,H;Trojanowski,JQ
通讯作者：
Trojanowski,JQ
DOI：
10.1073/pnas.83.11.4044
发表时间：
1986-06-01
影响因子：
11.1
作者：
KOSIK, KS;JOACHIM, CL;SELKOE, DJ
通讯作者：
SELKOE, DJ
影响因子：
--
作者：
PAPASOZOMENOS, SC;BINDER, LI
通讯作者：
BINDER, LI