Insulin resistance in lean and overweight non-diabetic Caucasian adults: Study of its relationship with liver triglyceride content, waist circumference and BMI.
Insulin resistance in lean and overweight non-diabetic Caucasian adults: Study of its relationship with liver triglyceride content, waist circumference and BMI.
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DOI：
10.1371/journal.pone.0192663
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Gonzalez-Calvin JL
中科院分区：
文献类型：
--
作者：
Gonzalez-Cantero J;Martin-Rodriguez JL;Gonzalez-Cantero A;Arrebola JP;Gonzalez-Calvin JL
胰岛素抵抗是2型糖尿病（DM-2）的病理生理学前兆，其与肥胖或代谢综合征患者非酒精性脂肪性肝病（NAFLD）的关系已被广泛研究，不仅使用超声，而且还使用肝活检或质子磁共振波谱（H1-MRS）来评估肝脏脂肪含量。相比之下，还没有使用H1-MRS或肝活检定量肝脏甘油三酯含量来研究瘦或超重白人个体的胰岛素抵抗和NAFLD。我们的目的是研究肥胖和超重的白种人是否存在胰岛素抵抗，并探讨其与肝脏甘油三酯含量、腰围（作为内脏肥胖的代表）、BMI和心脏代谢危险因素的可能关系。在113名非肥胖、非糖尿病个体中进行了一项横断面研究，这些个体被归类为超重（BMI 25-29.9 kg/m2）或偏瘦（BMI 19.5-24.9 kg/m2）。用3 T H1-MRS定量肝脏甘油三酯含量。NAFLD定义为肝脏甘油三酯含量> 5.56%。测定胰岛素抵抗（HOMA-IR）、血清脂联素和肿瘤坏死因子（TNF）。HOMA-IR与肝脏甘油三酯含量显著相关（r：0.76; p<0.0001）。肥胖伴NAFLD组的HOMA-IR显著高于肥胖不伴NAFLD组（p<0.001），血清脂联素显著低于肥胖不伴NAFLD组（p<0.05）。胰岛素抵抗与NAFLD独立相关，但与腰围或BMI无关。回归分析显示，肝脏甘油三酯含量是胰岛素抵抗的最重要的决定因素（P<0.01）。我们的研究结果表明，NAFLD，一旦建立，似乎是参与胰岛素抵抗和心脏代谢的危险因素以上和非肥胖，非糖尿病白人个体的腰围和BMI。
Insulin resistance is the pathophysiological precursor of type 2 diabetes mellitus (DM-2), and its relationship with non-alcoholic fatty liver disease (NAFLD) has been widely studied in patients with obesity or metabolic syndrome using not only ultrasound but also liver biopsies or proton magnetic resonance spectroscopy (H1-MRS) to assess liver fat content. In contrast, there are no studies on insulin resistance and NAFLD in lean or overweight Caucasian individuals using H1-MRS or liver biopsies for the quantification of hepatic triglyceride content. Our objectives were to study the presence of insulin resistance in lean and overweight Caucasian adults and investigate its possible relationship with liver triglyceride content, waist circumference (as proxy of visceral adiposity), BMI, and cardiometabolic risk factors. A cross-sectional study was conducted in 113 non-obese, non-diabetic individuals classified as overweight (BMI 25–29.9 kg/m2) or lean (BMI 19.5–24.9 kg/m2). Hepatic triglyceride content was quantified by 3T H1-MRS. NAFLD was defined as hepatic triglyceride content >5.56%. Insulin resistance (HOMA-IR), serum adiponectin, and tumor necrosis factor (TNF) were determined. HOMA-IR was significantly correlated with hepatic triglyceride content (r:0.76; p<0.0001). The lean-with-NAFLD group had significantly higher HOMA-IR (p<0.001) and lower serum adiponectin (p<0.05) than the overweight-without-NAFLD group. Insulin resistance was independently associated with NAFLD but not with waist circumference or BMI. Regression analysis showed hepatic triglyceride content to be the most important determinant of insulin resistance (p<0.01). Our findings suggest that NAFLD, once established, seems to be involved in insulin resistance and cardio-metabolic risk factors above and beyond waist circumference and BMI in non-obese, non-diabetic Caucasian individuals.
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DOI：
10.1002/hep.26455
发表时间：
2013-12
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Noureddin M;Lam J;Peterson MR;Middleton M;Hamilton G;Le TA;Bettencourt R;Changchien C;Brenner DA;Sirlin C;Loomba R
通讯作者：
Loomba R
影响因子：
9.8
作者：
Feldman, Alexandra;Eder, Sebastian K.;Aigner, Elmar
通讯作者：
Aigner, Elmar
影响因子：
7.2
作者：
Karelis, A;Brochu, M;Rabasa-Lhoret, R
通讯作者：
Rabasa-Lhoret, R
影响因子：
6.7
作者：
Leite, Nathalie C.;Salles, Gil F.;Cardoso, Claudia R. L.
通讯作者：
Cardoso, Claudia R. L.
影响因子：
5.8
作者：
Gonzalez-Calvin, Jorge L.;Mundi, Jose L.;Martin-Ibanez, Jose J.
通讯作者：
Martin-Ibanez, Jose J.