Somatic copy number alteration predicts clinical benefit of lung adenocarcinoma patients treated with cytokine-induced killer plus chemotherapy.
Somatic copy number alteration predicts clinical benefit of lung adenocarcinoma patients treated with cytokine-induced killer plus chemotherapy.
复制标题
DOI：
10.1038/s41417-021-00422-5
复制
发表时间：
2022-08
影响因子：
6.4
通讯作者：
Yang, Lili
中科院分区：
文献类型：
--
作者：
Kou, Fan;Wu, Lei;Zhu, Ye;Li, Baihui;Huang, Ziqi;Ren, Xiubao;Yang, Lili
Somatic copy number alterations (SCNA), which are widespread in cancer, can predict the efficacy of immune checkpoint inhibitors in non-small-cell lung cancer (NSCLC). However, the usefulness of SCNA for predicting the survival of patients treated with cytokine-induced killer (CIK) cells or chemotherapy (CT) is unknown. This study aimed to explore the correlation between SCNA and clinical outcome in NSCLC patients treated with CIK + CT or CT alone. We performed whole-exome sequencing on 45 NSCLC patients treated with CIK + CT, as well as 305 NSCLC patients treated with CT alone, from The Cancer Genome Atlas, which showed SCNA had a superiority in predicting the progression-free survival (PFS) over tumor mutation burden (TMB) and SCNA + TMB in NSCLC patients treated with CIK + CT, especially in lung adenocarcinoma, while SCNA could not predict the efficacy of CT alone. Additionally, we investigated the association between SCNA and immune cell infiltration by RNA sequencing and immunohistochemistry. The results revealed that SCNA was negatively associated with the expression of dendritic cells. Collectively, this study revealed a negative correlation between SCNA and response to CIK + CT and showed that SCNA is a predictive indicator in LUAD patients treated with CIK + CT.
登录
查看更多内容
影响因子：
4.6
作者：
Kanda Y;Osaki M;Onuma K;Sonoda A;Kobayashi M;Hamada J;Nicolson GL;Ochiya T;Okada F
通讯作者：
Okada F
DOI：
10.1038/nrm2718
发表时间：
2009-07
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
通讯作者：
--
影响因子：
30.8
作者：
Zack, Travis I.;Schumacher, Steven E.;Carter, Scott L.;Cherniack, Andrew D.;Saksena, Gordon;Tabak, Barbara;Lawrence, Michael S.;Zhang, Cheng-Zhong;Wala, Jeremiah;Mermel, Craig H.;Sougnez, Carrie;Gabriel, Stacey B.;Hernandez, Bryan;Shen, Hui;Laird, Peter W.;Getz, Gad;Meyerson, Matthew;Beroukhim, Rameen
通讯作者：
Beroukhim, Rameen
影响因子：
8
作者：
Gupta SC;Singh R;Asters M;Liu J;Zhang X;Pabbidi MR;Watabe K;Mo YY
通讯作者：
Mo YY
影响因子：
5.8
作者：
Li, Runmei;Wang, Changli;Li, Hui
通讯作者：
Li, Hui