Effects of naltrexone on post-abstinence alcohol drinking in C57BL/6NCRL and DBA/2J mice.
Effects of naltrexone on post-abstinence alcohol drinking in C57BL/6NCRL and DBA/2J mice.
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DOI：
10.1016/j.pnpbp.2013.03.002
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发表时间：
2013-07-01
影响因子：
5.6
通讯作者：
Yu, Lei
中科院分区：
文献类型：
--
作者：
Tomie, Arthur;Azogu, Idu;Yu, Lei
本实验评价了非选择性阿片受体拮抗剂纳洛酮对C57 BL/6 NCRL和DBA/2 J雄性小鼠戒酒后饮酒的影响。采用家庭笼2瓶（酒精vs.水）自由选择程序。在预禁欲期间，DBA/2 J小鼠的酒精摄入量相对于C57 BL/6 NCRL小鼠低得多，并且在接受3%或10%酒精浓度的组中观察到这种品系差异。四天的禁欲期有效地减少了酒精摄入量（即，负酒精剥夺效应，负ADE），但对C57 BL/6 NCRL小鼠的酒精摄入量没有影响。两组接受3%酒精训练的人都接受了第二个为期四天的戒酒期，评估了急性服用纳曲酮或生理盐水对戒酒后饮酒的影响。与C57 BL/6 NCRL小鼠相比，纳洛酮在减少DBA/2 J小鼠戒断后饮用3%酒精方面更有效。在DBA/2 J小鼠中，相对于注射生理盐水的对照组，纳洛酮进一步降低了戒酒后低水平的酒精摄入量。因此，DBA/2 J小鼠的低基线饮酒水平在4天戒断期（阴性ADE）进一步降低，并且这种抑制的戒断后饮酒水平通过纳曲酮急性给药进一步降低。结果表明，纳洛酮可有效地进一步降低由阴性ADE引起的低水平饮酒。
The present experiment evaluated the effects of naltrexone, a non-selective opioid receptor antagonist, on post-abstinence alcohol drinking in C57BL/6NCRL and DBA/2J male mice. Home cage 2-bottle (alcohol vs. water) free-choice procedures were employed. During the pre-abstinence period, alcohol intake was much lower for the DBA/2J mice relative to the C57BL/6NCRL mice, and this strain difference was observed for groups receiving either 3% or 10% alcohol concentrations. The four-day abstinence period effectively reduced alcohol intakes (i.e., a negative alcohol deprivation effect, negative ADE) in both groups of DBA/2J mice, but had no effect on alcohol intakes in either group of C57BL/6NCRL mice. Both groups trained with 3% alcohol received the second four-day abstinence period, where the effects of acute administration of either naltrexone or saline on post-abstinence alcohol drinking were assessed. Naltrexone was more effective in reducing post-abstinence drinking of 3% alcohol in the DBA/2J mice than in the C57BL/6NCRL mice. In the DBA/2J mice, naltrexone further reduced, relative to saline-injected controls, the low levels of post-abstinence alcohol intake. Thus, the low baseline levels of alcohol drinking in DBA/2J mice were further diminished by the four-day abstinence period (negative ADE), and this suppressed post-abstinence level of alcohol drinking was still further reduced by acute administration of naltrexone. The results indicate that naltrexone is effective in reducing further the low levels of alcohol drinking induced by the negative ADE.
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影响因子：
3.4
作者：
Escher, Tobie;Mittleman, Guy
通讯作者：
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影响因子：
3.4
作者：
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通讯作者：
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DOI：
10.1111/j.1530-0277.2011.01528.x
发表时间：
2011-10-01
影响因子：
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作者：
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通讯作者：
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DOI：
10.1037/h0043100
发表时间：
1964-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
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作者：
FULLER, JL
通讯作者：
FULLER, JL
影响因子：
2.3
作者：
Goodwin, FLW;Campisi, M;Amit, Z
通讯作者：
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