The Placebo-Controlled Effect of Percutaneous Coronary Intervention on Exercise Induced Changes in Anti-Malondialdehyde-LDL Antibody Levels in Stable Coronary Artery Disease: A Substudy of the ORBITA Trial.
The Placebo-Controlled Effect of Percutaneous Coronary Intervention on Exercise Induced Changes in Anti-Malondialdehyde-LDL Antibody Levels in Stable Coronary Artery Disease: A Substudy of the ORBITA Trial.
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经皮冠状动脉干预对运动诱导的抗甲醛-LDL抗体水平的变化的安慰剂控制作用：稳定的冠状动脉疾病：Orbita试验的一种替代。
DOI：
10.3389/fcvm.2021.757030
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发表时间：
2021
影响因子：
3.6
通讯作者：
Al-Lamee RK
中科院分区：
文献类型：
--
作者：
Hartley A;Shun-Shin M;Caga-Anan M;Rajkumar C;Nowbar AN;Foley M;Francis DP;Haskard DO;Khamis RY;Al-Lamee RK
目的：丙二醛修饰的低密度脂蛋白是氧化型低密度脂蛋白的重要组成部分。运动对丙二醛-低密度脂蛋白和抗-丙二醛-低密度脂蛋白抗体水平的影响尚不清楚。此外，目前尚不清楚冠状动脉疾病患者是否可以通过经皮冠状动脉介入治疗(PCI)来改变这些指标。方法：稳定性心绞痛血管成形术最佳药物治疗(ORBITA)试验是首个关于冠状动脉介入治疗与安慰剂治疗心绞痛的多中心随机对照试验。在4个时间点采集血清样本：随机化前(P1)和运动后(P2)和随机化后(PCI或安慰剂手术后6周)，运动前(P3)和运动后(P4)。使用实验室开发的丙二醛-低密度脂蛋白(经载脂蛋白B调整)和抗丙二醛-低密度脂蛋白抗体进行ELISA检测。结果：参加Orbita试验的2 0 0例严重单支冠状动脉病变患者(年龄6 6.1岁，女性占2 8%)中，196例有血液可供分析。在随机化前(P2-P1)运动后，调整后的丙二醛-低密度脂蛋白没有显著变化(−0.001，95%CI−0.004至0.001；p=0.287)，但免疫球蛋白和免疫球蛋白M抗丙二醛-低密度脂蛋白显著下降(−0.022，95%CI−0.029至−0.014，p<；0.0001；−0.016，95%CI−0.024至−0.008，p=0.0002)。经皮冠状动脉介入治疗对运动前丙二醛-低密度脂蛋白(p=0.102)、免疫球蛋白G(p=0.444)或免疫球蛋白M抗丙二醛-低密度脂蛋白(p=0.909)均无显著影响。经皮冠状动脉介入治疗也不影响运动诱导的丙二醛-低密度脂蛋白(p=0.605)、免疫球蛋白G(p=0.725)或免疫球蛋白M抗丙二醛-低密度脂蛋白(p=0.171)这些标志物(控制P1、P2和P3的P4)的变化。应激反应的预随机化缺血并不影响这些相互作用。结论：运动导致严重单支冠脉疾病患者体内抗oxLDL抗体的急剧下降，可能表明通过先天免疫系统诱导体内平衡清除。然而，经皮冠状动脉介入治疗并没有改善这种效果。
Aim: Malondialdehyde-modified low-density lipoprotein (MDA-LDL) forms a significant component of oxidised LDL. The effects of exercise on levels of MDA-LDL and anti-MDA-LDL antibodies are not well-understood. Furthermore, it is not known whether these can be modified in patients with coronary artery disease by percutaneous coronary intervention (PCI). Methods: The Objective Randomised Blinded Investigation with optimal medical Therapy of Angioplasty in stable angina (ORBITA) trial was the first blinded, multi-centre randomised trial of PCI vs. placebo procedure for angina relief. Serum samples were available at four time-points: pre-randomisation pre- (P1) and post- (P2) exercise and post-randomisation (6-weeks following the PCI or placebo procedure), pre- (P3) and post- (P4) exercise. ELISAs were performed using laboratory-developed assays for MDA-LDL (adjusted for Apolipoprotein B) and anti-MDA-LDL antibodies. Results: One hundred ninety-six of the 200 patients (age 66.1 [SD 8.99] years, 28% female) with severe single vessel coronary artery disease suitable for PCI enrolled in the ORBITA trial had blood available for analysis. With exercise at pre-randomisation (P2–P1) there was no significant change in adjusted MDA-LDL (−0.001, 95% CI −0.004 to 0.001; p = 0.287); however, IgG and IgM anti-MDA-LDL significantly declined (−0.022, 95% CI −0.029 to −0.014, p < 0.0001; −0.016, 95% CI −0.024 to −0.008, p = 0.0002, respectively). PCI did not have a significant impact on either the pre-exercise values (P3 controlling for P1) of MDA-LDL (p = 0.102), IgG (p = 0.444) or IgM anti-MDA-LDL (p = 0.909). Nor did PCI impact the exercise induced changes in these markers (P4 controlling for P1, P2, and P3) for MDA-LDL (p = 0.605), IgG (p = 0.725) or IgM anti-MDA-LDL (p = 0.171). Pre-randomisation ischaemia on stress echo did not impact these interactions. Conclusions: Exercise results in an acute reduction in anti-oxLDL antibodies in patients with severe single vessel coronary disease, possibly indicating an induction in homoeostatic clearance via the innate immune system. However, PCI did not ameliorate this effect.
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影响因子：
4
作者：
Leibundgut G;Lee JH;Strauss BH;Segev A;Tsimikas S
通讯作者：
Tsimikas S
DOI：
10.1249/mss.0b013e31823822cc
发表时间：
2012-04-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Kosola, Jussi;Ahotupa, Markku;Vasankari, Tommi
通讯作者：
Vasankari, Tommi
影响因子：
168.9
作者：
Al-Lamee, Rasha;Thompson, David;Francis, Darrel P.
通讯作者：
Francis, Darrel P.
影响因子：
--
作者：
Chang, Shang-Hung;Johns, Michael;Haskard, Dorian O.
通讯作者：
Haskard, Dorian O.
影响因子：
2.8
作者：
Fujii, H;Shimizu, M;Genda, A
通讯作者：
Genda, A