Diversity of bacterial chemosensory systems.

Diversity of bacterial chemosensory systems.
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细菌化学感受系统的多样性。

DOI:
10.1016/j.mib.2021.01.016
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发表时间:
2021-06
影响因子:
5.4
通讯作者:
Zhulin IB
Zhulin IB
中科院分区:
生物学2区
文献类型:
--
作者:
Gumerov VM;Andrianova EP;Zhulin IB

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化学感受系统控制着细菌和古细菌中最复杂、最特殊的信号转导模式。它们由几种核心和辅助蛋白质组成,这些蛋白质高度组织化,以便对不断变化的环境条件做出快速反应。化学感受途径已在少数模式生物中进行了深入研究,并在大约三十个物种中至少在一定程度上进行了实验表征。然而,全基因组分析显示它们存在于数千个测序的微生物基因组中。实验和计算的研究揭示了大量的多样性,系统设计,功能调节,细胞定位和系统分布的化学感受途径。在这里,我们总结了进展,并揭示了差距,我们目前的理解多样性的化学感受系统。
Chemosensory systems control the most complex, specialized mode of signal transduction in bacteria and archaea. They are composed of several core and auxiliary protein components that are highly organized in order to deliver a fast response to changing environmental conditions. Chemosensory pathways have been studied in-depth in a handful of model organisms and experimentally characterized at least to some degree in approximately thirty species. However, genome-wide analyses have revealed their presence in thousands of sequenced microbial genomes. Both experimental and computational studies uncovered substantial diversity in system design, functional regulation, cellular localization and phyletic distribution of chemosensory pathways. Here, we summarize advances and expose gaps in our current understanding of the diversity of chemosensory systems.
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期刊: MBIO
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