Is the Therapeutic Mechanism of Repetitive Transcranial Magnetic Stimulation in Cognitive Dysfunctions of Depression Related to the Neuroinflammatory Processes in Depression?
Is the Therapeutic Mechanism of Repetitive Transcranial Magnetic Stimulation in Cognitive Dysfunctions of Depression Related to the Neuroinflammatory Processes in Depression?
复制标题
重复经颅磁刺激治疗抑郁症认知功能障碍的机制是否与抑郁症的神经炎症过程有关？
DOI：
10.3389/fpsyt.2022.834425
复制
发表时间：
2022
影响因子：
4.7
通讯作者：
Monji A
中科院分区：
文献类型：
--
作者：
Tateishi H;Mizoguchi Y;Monji A
据报道，抑郁症的终生患病率> 10%，它是一种重要的疾病，在很长一段时间内会导致各种残疾。神经炎症过程经常被报道与抑郁症的病理生理密切相关。大约三分之一的抑郁症是已知的难治性抑郁症（TRD），其中的症状是难以充分治疗的。认知功能障碍是抑郁症最重要的症状之一，严重影响抑郁症患者的康复。重复经颅磁刺激（rTMS）是一种微创且有效的TRD治疗方法，也被认为对抑郁症的认知功能障碍有效。由于rTMS治疗机制的细节仍不清楚，我们一直在进行研究，以阐明rTMS的治疗机制，特别是关注抑郁症的认知功能障碍。在本综述中，我们提出了我们的最新研究结果，并从抑郁症的神经炎症假说的角度进行讨论，同时引用相关文献。
The lifetime prevalence of depression is reported to be >10%, and it is an important illness that causes various disabilities over a long period of life. Neuroinflammation process is often reported to be closely linked to the pathophysiology of depression. Approximately one-third of depression is known to be treatment-resistant depression (TRD), in which the symptoms are refractory to adequate treatment. Cognitive dysfunction is one of the most important symptoms of depression that impedes the rehabilitation of patients with depression. Repetitive transcranial magnetic stimulation (rTMS) is a minimally invasive and effective treatment for TRD and is also known to be effective in cognitive dysfunction in depression. Since the details of the therapeutic mechanism of rTMS are still unknown, we have been conducting studies to clarify the therapeutic mechanism of rTMS, especially focusing on cognitive dysfunction in depression. In the present review, we present our latest results and discuss them from the standpoint of the neuroinflammation hypothesis of depression, while citing relevant literature.
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DOI：
10.1016/j.bbih.2021.100278
发表时间：
2021-08
期刊：
Brain, behavior, & immunity - health
影响因子：
--
作者：
Mac Giollabhui N
通讯作者：
Mac Giollabhui N
影响因子：
10.6
作者：
Dowlati, Yekta;Herrmann, Nathan;Lanctot, Krista L.
通讯作者：
Lanctot, Krista L.
影响因子：
3.7
作者：
Haroon E;Daguanno AW;Woolwine BJ;Goldsmith DR;Baer WM;Wommack EC;Felger JC;Miller AH
通讯作者：
Miller AH
DOI：
10.1097/yct.0b013e3181e6317d
发表时间：
2011-03
期刊：
The journal of ECT
影响因子：
--
作者：
Kozel FA;Johnson KA;Nahas Z;Nakonezny PA;Morgan PS;Anderson BS;Kose S;Li X;Lim KO;Trivedi MH;George MS
通讯作者：
George MS
DOI：
10.1590/1516-4446-2020-0650
发表时间：
2020-11
期刊：
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
影响因子：
--
作者：
Gutiérrez-Rojas L;Porras-Segovia A;Dunne H;Andrade-González N;Cervilla JA
通讯作者：
Cervilla JA