Selective loss of beta 2-microglobulin mRNA in human colon carcinoma
Selective loss of beta 2-microglobulin mRNA in human colon carcinoma
复制标题
人类结肠癌中 β2-微球蛋白 mRNA 的选择性丢失
DOI：
--
复制
发表时间：
1989
影响因子：
15.3
通讯作者：
Susanne Kocht
中科院分区：
文献类型：
--
作者：
F. Momburg;Susanne Kocht
Expression of MHC class I antigens requires the intracellular assembly of HLA-A,B,C H chains and beta 2-microglobulin (beta 2m). We have investigated the expression of free H chain, beta 2m, and their mRNAs in tissue sections of colon carcinomas that were defective for the native two-chain molecule. In all of these tumors, beta 2m protein and mRNA were found to be completely absent from the neoplastic cells, whereas free H chains and their respective mRNAs were present in abundance in the tumor cell cytoplasm. The selective abrogation of beta 2m expression represents a unique mechanism leading to a complete loss of class I antigen surface expression in vivo.
F9 畸胎癌干细胞中组织相容性抗原 (H-2) 和 β2-微球蛋白表达的控制。
DOI：
10.1073/pnas.78.9.5754
发表时间：
1981
影响因子：
11.1
作者：
Croce,CM;Linnenbach,A;Huebner,K;Parnes,JR;Margulies,DH;Appella,E;Seidman,JG
通讯作者：
Seidman,JG
荧光 β-2-微球蛋白与细胞表面的特定关联。
DOI：
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发表时间：
1988
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Hochman,JH;Shimizu,Y;DeMars,R;Edidin,M
通讯作者：
Edidin,M