Targeting non-coding RNAs in unstable atherosclerotic plaques: Mechanism, regulation, possibilities, and limitations.
Targeting non-coding RNAs in unstable atherosclerotic plaques: Mechanism, regulation, possibilities, and limitations.
复制标题
靶向不稳定动脉粥样硬化斑块中的非编码 RNA：机制、调节、可能性和局限性。
DOI：
10.7150/ijbs.62506
复制
发表时间：
2021
影响因子：
9.2
通讯作者：
Yu T
中科院分区：
文献类型：
--
作者：
Li X;Yang Y;Wang Z;Jiang S;Meng Y;Song X;Zhao L;Zou L;Li M;Yu T
由动脉硬化引起的心血管疾病（CVD）是全球死亡和残疾的主要原因。在动脉粥样硬化的晚期，动脉粥样硬化斑块在血管中逐渐扩张，导致血管狭窄。当不稳定的斑块破裂并福尔斯脱落时，它阻塞了血管，引起血管血栓形成，导致中风、心肌梗塞等一系列危及人们生命的严重疾病。因此，调节斑块稳定性是用于解决与CVD相关的高死亡率的主要手段。动脉粥样硬化斑块的发展是血管细胞凋亡、脂质代谢紊乱、炎性细胞浸润、血管平滑肌细胞迁移、新生血管浸润等多方面因素综合作用的结果。近年来，非编码RNA（non-coding RNA，ncRNA）通过影响血管系统及其相关细胞的生物学功能，在动脉粥样硬化斑块形成的病理生理过程中发挥重要作用。本文旨在全面综述动脉粥样硬化斑块破裂易感性的调控机制，讨论目前治疗斑块不稳定性方法的局限性，并强调ncRNA作为新型诊断生物标志物和潜在治疗策略的潜在临床价值，以改善斑块稳定性和降低主要心血管事件的风险。
Cardiovascular diseases (CVDs) caused by arteriosclerosis are the leading cause of death and disability worldwide. In the late stages of atherosclerosis, the atherosclerotic plaque gradually expands in the blood vessels, resulting in vascular stenosis. When the unstable plaque ruptures and falls off, it blocks the vessel causing vascular thrombosis, leading to strokes, myocardial infarctions, and a series of other serious diseases that endanger people's lives. Therefore, regulating plaque stability is the main means used to address the high mortality associated with CVDs. The progression of the atherosclerotic plaque is a complex integration of vascular cell apoptosis, lipid metabolism disorders, inflammatory cell infiltration, vascular smooth muscle cell migration, and neovascular infiltration. More recently, emerging evidence has demonstrated that non-coding RNAs (ncRNAs) play a significant role in regulating the pathophysiological process of atherosclerotic plaque formation by affecting the biological functions of the vasculature and its associated cells. The purpose of this paper is to comprehensively review the regulatory mechanisms involved in the susceptibility of atherosclerotic plaque rupture, discuss the limitations of current approaches to treat plaque instability, and highlight the potential clinical value of ncRNAs as novel diagnostic biomarkers and potential therapeutic strategies to improve plaque stability and reduce the risk of major cardiovascular events.
登录
查看更多内容
影响因子：
4.4
作者：
Aukrust, Pal;Sandberg, Wiggo J.;Ueland, Thor
通讯作者：
Ueland, Thor
P2Y2受体的内皮细胞特异性缺失促进了动脉粥样硬化易感的Apoe-Null小鼠的斑块稳定性。
DOI：
10.1161/atvbaha.116.308561
发表时间：
2017-01
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Chen X;Qian S;Hoggatt A;Tang H;Hacker TA;Obukhov AG;Herring PB;Seye CI
通讯作者：
Seye CI
主动脉夹层中的非编码 RNA：从生物标志物到治疗靶点
影响因子：
5.3
作者：
Cheng M;Yang Y;Xin H;Li M;Zong T;He X;Yu T;Xin H
通讯作者：
Xin H
MicroRNA-124-3p 通过靶向血管平滑肌细胞中的脯氨酰 4-羟化酶亚基 α-1 (P4HA1) 来抑制动脉粥样硬化斑块中的胶原蛋白合成。
影响因子：
5.3
作者：
Chen, Wei'jia;Yu, Fangpu;Zhang, Mei
通讯作者：
Zhang, Mei
影响因子：
3.7
作者：
Bras JP;Silva AM;Calin GA;Barbosa MA;Santos SG;Almeida MI
通讯作者：
Almeida MI