Determinants of First-Ever Stroke Severity in West Africans: Evidence From the SIREN Study.
Determinants of First-Ever Stroke Severity in West Africans: Evidence From the SIREN Study.
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DOI：
10.1161/jaha.122.027888
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发表时间：
2023-06-20
影响因子：
5.4
通讯作者：
SIREN
中科院分区：
文献类型：
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作者：
Adebayo, Oladimeji;Akpa, Onoja;Asowata, Osahon J.;Fakunle, Adekunle;Sarfo, Fred S.;Akpalu, Albert;Wahab, Kolawole;Obiako, Reginald;Komolafe, Morenikeji;Owolabi, Lukman;Osaigbovo, Godwin O.;Okekunle, Akinkunmi Paul;Sunmonu, Taofiki;Tiwari, Hemant K.;Jenkins, Carolyn;Arulogun, Oyedunni;Appiah, Lambert;Akinyemi, Joshua;Adeoye, Abiodun M.;Ogbole, Godwin;Yaria, Joseph;Arnett, Donna;Adebayo, Philip;Calys-Tagoe, Benedict;Ogah, Okechukwu S.;Balogun, Olayemi;Ogunjimi, Luqman;Mensah, Yaw;Agbogu-Ike, Obiageli U.;Akinyemi, Rufus;Ovbiagele, Bruce;Owolabi, Mayowa O.;SIREN
基线卒中严重程度可能是撒哈拉以南非洲卒中结局不佳的部分原因。然而，关于土著非洲人中风严重程度的决定因素的信息很少。我们试图在SIREN（中风调查研究和教育网络）研究中确定与西非人中风严重程度相关的因素。临床诊断为中风，并经脑神经影像学证实。重度卒中定义为卒中轻度量表评分≤5。构建多变量logistic回归模型，以确定与卒中严重程度相关的因素，95% CI和5% 1型错误的标称截止值。共纳入3660例卒中病例。总体而言，50.7%的患者患有重度卒中，包括47.6%的缺血性卒中和56.1%的脑出血。与严重中风独立相关的因素是肉类消费（调整后的比值比[aOR]，1.97 [95% CI，1.43-2.73]），低蔬菜摄入量（aOR，2.45 [95% CI，1.93-3.12]）和病变体积，aOR为1.67（95% CI，1.03-2.72），病变体积>30 cm 3的aOR为3.88（95% CI，1.93-7.81）。与腔隙性卒中相比，重度缺血性卒中与完全前循环梗死（aOR，3.1 [95%CI，1.5-6.9]）、后循环梗死（aOR，2.2 [95%CI，1.1-4.2]）和部分前循环梗死（aOR，2.0 [95%CI，1.2-3.3]）独立相关。年龄增加（aOR，2.6 [95% CI，1.3-5.2]）和病变体积>30 cm 3（aOR，6.2 [95% CI，2.0-19.3]）与重度脑出血独立相关。严重中风在西非土著人中很常见，可改变的饮食因素与之独立相关。这些因素可以有针对性地减少严重中风的负担。
Baseline stroke severity is probably partly responsible for poor stroke outcomes in sub‐Saharan Africa. However, there is a paucity of information on determinants of stroke severity among indigenous Africans. We sought to identify the factors associated with stroke severity among West Africans in the SIREN (Stroke Investigative Research and Educational Networks) study. Stroke was diagnosed clinically and confirmed with brain neuroimaging. Severe stroke was defined as a Stroke Levity Scale score of ≤5. A multivariate logistic regression model was constructed to identify factors associated with stroke severity at 95% CI and a nominal cutoff of 5% type 1 error. A total of 3660 stroke cases were included. Overall, 50.7%% had severe stroke, including 47.6% of all ischemic strokes and 56.1% of intracerebral hemorrhage. Factors independently associated with severe stroke were meat consumption (adjusted odds ratio [aOR], 1.97 [95% CI, 1.43–2.73]), low vegetable consumption (aOR, 2.45 [95% CI, 1.93–3.12]), and lesion volume, with an aOR of 1.67 (95% CI, 1.03–2.72) for lesion volume of 10 to 30 cm3 and aOR of 3.88 (95% CI, 1.93–7.81) for lesion volume >30 cm3. Severe ischemic stroke was independently associated with total anterior circulation infarction (aOR, 3.1 [95% CI, 1.5–6.9]), posterior circulation infarction (aOR, 2.2 [95% CI, 1.1–4.2]), and partial anterior circulation infarction (aOR, 2.0 [95% CI, 1.2–3.3]) compared with lacunar stroke. Increasing age (aOR, 2.6 [95% CI, 1.3–5.2]) and lesion volume >30 cm3 (aOR, 6.2 [95% CI, 2.0–19.3]) were independently associated with severe intracerebral hemorrhage. Severe stroke is common among indigenous West Africans, where modifiable dietary factors are independently associated with it. These factors could be targeted to reduce the burden of severe stroke.
影响因子：
3.7
作者：
Adeoye AM;Ovbiagele B;Kolo P;Appiah L;Aje A;Adebayo O;Sarfo F;Akinyemi J;Adekunle G;Agyekum F;Shidali V;Ogah O;Lackland D;Gebregziabher M;Arnett D;Tiwari HK;Akinyemi R;Olagoke OO;Oguntade AS;Olunuga T;Uwanruochi K;Jenkins C;Adadey P;Iheonye H;Owolabi L;Obiako R;Akinjopo S;Armstrong K;Akpalu A;Fakunle A;Saulson R;Aridegbe M;Olowoyo P;Osaigbovo G;Akpalu J;Fawale B;Adebayo P;Arulogun O;Ibinaiye P;Agunloye A;Ishaq N;Wahab K;Akpa O;Adeleye O;Bock-Oruma A;Ogbole G;Melikam S;Yaria J;Ogunjimi L;Salaam A;Sunmonu T;Makanjuola A;Farombi T;Laryea R;Uvere E;Kehinde S;Chukwuonye I;Azuh P;Komolafe M;Akintunde A;Obiabo O;Areo O;Kehinde I;Amusa AG;Owolabi M;SIREN Team as part of H3Africa Consortium
通讯作者：
SIREN Team as part of H3Africa Consortium