Anger management: Mechanisms of glutamate receptor-mediated synaptic plasticity underlying animal aggression.
Anger management: Mechanisms of glutamate receptor-mediated synaptic plasticity underlying animal aggression.
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DOI:
10.1016/j.biocel.2021.106120
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发表时间:
2022-01
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影响因子:
--
通讯作者:
Nordman JC
中科院分区:
文献类型:
--
作者:
Nordman JC
Excessive and recurring violent aggression is a serious concern for society and a symptom of many psychiatric diseases. Substance abuse, attack experience, and social and traumatic stress increase vulnerability to developing this type of aggression. Glutamate receptors are an intriguing target for long-term treatment. This review will assess the importance of glutamate receptors and glutamatergic pathways in aggression, focusing on the role of glutamate receptor-mediated synaptic plasticity in experience-dependent long-lasting aggression. By synthesizing what is known about glutamatergic systems in aggression, it is hoped more effective treatments can be developed.
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