Assessment of a combined spin- and gradient-echo (SAGE) DSC-MRI method for preclinical neuroimaging.
Assessment of a combined spin- and gradient-echo (SAGE) DSC-MRI method for preclinical neuroimaging.
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DOI：
10.1016/j.mri.2014.08.027
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发表时间：
2014-12
影响因子：
2.5
通讯作者：
Quarles, C. Chad
中科院分区：
文献类型：
--
作者：
Stokes, Ashley M.;Skinner, Jack T.;Quarles, C. Chad
关键词：
本研究的目的是优化和验证用于动态磁对比度磁共振成像的组合自旋和梯度回波（SAGE）序列，以获得临床前环境中的血流动力学参数。SAGE EPI序列应用于模型和体内大鼠脑（正常、肿瘤和中风组织）。部分和完整的傅立叶编码方案的实施和特点。测量脑血容量（CBV）、脑血流量（CBF）、平均通过时间（MTT）、血管直径指数（VSI）、体积传递常数（Ktranss）和血管外细胞外间隙体积分数（ve）。部分傅立叶编码提供了缩短的回波时间，具有可接受的SNR和时间稳定性，因此能够可靠地表征T2， 和T_1的变化。血流动力学参数CBV，CBF，梯度回波和自旋回波对比的MTT在肿瘤和中风进行了测定; VSI，Ktranss，并在肿瘤组织中进行了计算。SAGE EPI序列允许采集多个梯度回波和自旋回波，从而在临床前环境中获得灌注、渗透性和血管尺寸的测量值。部分傅立叶编码可用于最小化SAGE回波时间并可靠地量化动态T2和 变化该采集提供了对具有血管和灌注异常的脑组织中的血流动力学状态的更全面的评估。
The goal of this study was to optimize and validate a combined spin- and gradient-echo (SAGE) sequence for dynamic susceptibility-contrast magnetic resonance imaging to obtain hemodynamic parameters in a preclinical setting. The SAGE EPI sequence was applied in phantoms and in vivo rat brain (normal, tumor, and stroke tissue). Partial and full Fourier encoding schemes were implemented and characterized. Maps of cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT), vessel size index (VSI), volume transfer constant (Ktrans), and volume fraction of the extravascular extracellular space (ve) were obtained. Partial Fourier encoding provided shortened echo times with acceptable SNR and temporal stability, thus enabling reliable characterization of T2, and T1 in both phantoms and rat brain. The hemodynamic parameters CBV, CBF, and MTT for gradient-echo and spin-echo contrast were determined in tumor and stroke; VSI, Ktrans, and ve were also computed in tumor tissue. The SAGE EPI sequence allows the acquisition of multiple gradient- and spin-echoes, from which measures of perfusion, permeability, and vessel size can be obtained in a preclinical setting. Partial Fourier encoding can be used to minimize SAGE echo times and reliably quantify dynamic T2 and changes. This acquisition provides a more comprehensive assessment of hemodynamic status in brain tissue with vascular and perfusion abnormalities.
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