Cytokine storm plays a direct role in the morbidity and mortality from influenza virus infection and is chemically treatable with a single sphingosine-1-phosphate agonist molecule.
Cytokine storm plays a direct role in the morbidity and mortality from influenza virus infection and is chemically treatable with a single sphingosine-1-phosphate agonist molecule.
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DOI：
10.1007/978-3-319-05879-5_6
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发表时间：
2014
影响因子：
--
通讯作者：
Rosen H
中科院分区：
文献类型：
--
作者：
Oldstone MB;Rosen H
细胞因子风暴定义了一种失调和过度夸张的免疫反应，最常见的是伴随选定的病毒感染和几种自身免疫性疾病。新出现的和再出现的呼吸道感染，特别是流感、SARS和汉坦病毒引起相当大的医疗问题。它们的发病率和死亡率通常是细胞因子风暴的直接结果。本章主要介绍流感病毒感染和由此产生的细胞因子风暴。它提供了令人信服的证据，阐明了流感发病机制中的细胞因子风暴，并明确发现细胞因子风暴可通过针对鞘氨醇-1-磷酸受体（S1 PR）调节的治疗（特别是S1 P1 R激动剂治疗）进行化学处理。本文就S1 P1 R信号通路的作用机制及相关通路进行综述。
Cytokine storm defines a dysregulation of and an excessively exaggerated immune response most often accompanying selected viral infections and several autoimmune diseases. Newly emerging and re-emerging infections of the respiratory tract, especially influenza, SARS, and hantavirus post considerable medical problems. Their morbidities and mortalities are often a direct result of cytokine storm. This chapter visits primarily influenza virus infection and resultant cytokine storm. It provides the compelling evidence that illuminates cytokine storm in influenza pathogenesis and the clear findings that cytokine storm is chemically tractable by therapy directed toward sphingosine-1-phosphate receptor (S1PR) modulation, specifically S1P1R agonist therapy. The mechanism(s) of how S1P1R signaling works and the pathways involved are subjects of this review.
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