Intensive Blood Pressure Reduction and Spot Sign in Intracerebral Hemorrhage: A Secondary Analysis of a Randomized Clinical Trial.
Intensive Blood Pressure Reduction and Spot Sign in Intracerebral Hemorrhage: A Secondary Analysis of a Randomized Clinical Trial.
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DOI：
10.1001/jamaneurol.2017.1014
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发表时间：
2017-08-01
期刊：
影响因子：
29
通讯作者：
Antihypertensive Treatment of Acute Cerebral Hemorrhage II and Neurological Emergencies Treatment Trials Investigators
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文献类型：
--
作者：
Morotti A;Brouwers HB;Romero JM;Jessel MJ;Vashkevich A;Schwab K;Afzal MR;Cassarly C;Greenberg SM;Martin RH;Qureshi AI;Rosand J;Goldstein JN;Antihypertensive Treatment of Acute Cerebral Hemorrhage II and Neurological Emergencies Treatment Trials Investigators
The computed tomographic angiography (CTA) spot sign is associated with intracerebral hemorrhage (ICH) expansion and may mark those patients most likely to benefit from intensive blood pressure (BP) reduction. To investigate whether the spot sign is associated with ICH expansion across a wide range of centers and whether intensive BP reduction decreases hematoma expansion and improves outcome in patients with ICH and a spot sign. SCORE-IT (Spot Sign Score in Restricting ICH Growth) is a preplanned prospective observational study nested in the Antihypertensive Treatment of Acute Cerebral Hemorrhage II (ATACH-II) randomized clinical trial. Participants included consecutive patients with primary ICH who underwent a CTA within 8 hours from onset at 59 sites from May 15, 2011, through December 19, 2015. Data were analyzed for the present study from July 1 to August 31, 2016. Patients in ATACH-II were randomized to intensive (systolic BP target, <140 mm Hg) vs standard (systolic BP target, <180 mm Hg) BP reduction within 4.5 hours from onset. Expansion of ICH was defined as hematoma growth of greater than 33%, and an unfavorable outcome was defined as a 90-day modified Rankin Scale score of 4 or greater (range, 0–6). The association among BP reduction, ICH expansion, and outcome was investigated with multivariable logistic regression. A total of 133 patients (83 men [62.4%] and 50 women [37.6%]; mean [SD] age, 61.9 [13.1] years) were included. Of these, 53 (39.8%) had a spot sign, and 24 of 123 without missing data (19.5%) experienced ICH expansion. The spot sign was associated with expansion with sensitivity of 0.54 (95% CI, 0.34–0.74) and specificity of 0.63 (95% CI, 0.53–0.72). After adjustment for potential confounders, intensive BP treatment was not associated with a significant reduction of ICH expansion (relative risk, 0.83; 95% CI, 0.27–2.51; P = .74) or improved outcome (relative risk of 90-day modified Rankin Scale score ≥4, 1.24; 95% CI, 0.53–2.91; P = .62) in spot sign–positive patients. The predictive performance of the spot sign for ICH expansion was lower than in prior reports from single-center studies. No evidence suggested that patients with ICH and a spot sign specifically benefit from intensive BP reduction. clinicaltrials.gov Identifier: NCT01176565
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DOI：
10.3174/ajnr.a4810
发表时间：
2016-10
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Morotti A;Romero JM;Jessel MJ;Brouwers HB;Gupta R;Schwab K;Vashkevich A;Ayres A;Anderson CD;Gurol ME;Viswanathan A;Greenberg SM;Rosand J;Goldstein JN
通讯作者：
Goldstein JN
影响因子：
8.3
作者：
Hemphill, JC;Bonovich, DC;Johnston, SC
通讯作者：
Johnston, SC
DOI：
10.1056/nejmoa1603460
发表时间：
2016-09-15
期刊：
The New England journal of medicine
影响因子：
--
作者：
Qureshi AI;Palesch YY;Barsan WG;Hanley DF;Hsu CY;Martin RL;Moy CS;Silbergleit R;Steiner T;Suarez JI;Toyoda K;Wang Y;Yamamoto H;Yoon BW;ATACH-2 Trial Investigators and the Neurological Emergency Treatment Trials Network
通讯作者：
ATACH-2 Trial Investigators and the Neurological Emergency Treatment Trials Network
影响因子：
3.5
作者：
Qureshi AI;Palesch YY
通讯作者：
Palesch YY
影响因子：
48
作者：
van Asch, Charlotte J. J.;Luitse, Merel J. A.;Klijn, Catharina J. M.
通讯作者：
Klijn, Catharina J. M.