Impact of anemia on prognosis in tuberculosis patients.
Impact of anemia on prognosis in tuberculosis patients.
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贫血对结核病患者预后的影响。
DOI：
10.21037/atm-22-679
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发表时间：
2022-03
影响因子：
--
通讯作者：
Liu, Zhonghua
中科院分区：
文献类型：
--
作者：
Luo, Mengxing;Liu, Ming;Wu, Xiaocui;Wu, Yaxing;Yang, Hua;Qin, Lianhua;Yu, Fangyong;Hu, Yang;Liu, Zhonghua
贫血是结核病的危险因素之一，90%以上的结核病患者患有贫血。预后较差的结核病患者在治疗过程中以贫血为主。我们的研究目的是分析贫血对肺结核患者预后的影响，包括肺部结核分枝杆菌载量、肺部病理和临床因素。本研究将上海市155例结核病患者分为贫血-结核（A-TB）组和非贫血-结核（NA-TB）组。分析两组患者痰涂片细菌计数及痰涂片转化时间。我们评估了A-TB患者的肺部病理空腔和积液。采用Logistic回归分析探讨贫血与痰菌负荷和肺部病理的潜在相关性。我们比较了包括免疫因素和炎症细胞在内的临床因素。与NA-TB （n=89）组相比，A-TB组（n=66）在肺腔闭合（4.7±3.59∶10.56±7.42；P=0.036）和液体改善[4(30.77%)∶12(92.31%)]方面的肺损伤改善较差；P=0.001]。治疗开始时，免疫因子补体4 (C4) [0.25 (0.19, 0.295) vs. 0.3086±0.076；P=0.006]和c反应蛋白（CRP）[3.2（3.2, 21.5）比19.5 (6.25,78.35)]；P=0.016] A-TB与NA-TB的发病率显著高于A-TB。在治疗过程中，淋巴细胞（lym#）的绝对数量（P=0.0012, r=−0.3400）逐渐减少，单核细胞（MONO#）的绝对数量（P=0.0050, r=0.2968）、嗜碱性粒细胞（BASO#）的绝对数量（P=0.0213, r=0.2451）、红细胞分布宽度系数（RDW-CV） （P=0.0136, r=0.2651）逐渐增加，提示贫血性TB患者预后较差。贫血是结核病患者肺损伤的一个危险因素。在A-TB患者治疗期间，炎症因子和炎症细胞增加。
Anemia is one of the risk factors for tuberculosis (TB), and more than 90% of TB patients suffer from anemia. The majority tuberculosis patients who had poor prognosis experienced anemia during the course of treatment. The objective of our study is to analyse the influences of anemia on the prognosis of tuberculosis patients in terms of pulmonary M. tuberculosis loads, lung pathology, and clinical factors. In this retrospective cohort study, 155 TB patients in Shanghai were divided into the anemia-tuberculosis (A-TB) group and non-anemia-tuberculosis (NA-TB) group. We analysed bacteria counts in sputum smear and sputum smear conversion time between two groups. We evaluated the pulmonary pathology of cavity and effusion in A-TB patients. Logistic regression analysis was performed to explore the potential correlations of anemia with sputum bacterial load and pulmonary pathology. We compared clinical factors including the immune factors and inflammatory cells. Compared with the NA-TB (n=89) group, the A-TB group (n=66) had poorer improvement of lung injury in terms of cavity closure (4.7±3.59 vs. 10.56±7.42; P=0.036) and fluid improvement [4 (30.77%) vs. 12 (92.31%); P=0.001] during conventional treatment. At the start of treatment, the immune factors complement 4 (C4) [0.25 (0.19, 0.295) vs. 0.3086±0.076; P=0.006] and C-reactive protein (CRP) [3.2 (3.2, 21.5) vs. 19.5 (6.25, 78.35); P=0.016] were significantly higher in A-TB with NA-TB. During the course of treatment, the gradual decrease in the absolute number of lymphocytes (LYM#) (P=0.0012, r=−0.3400) and the gradual increase in the absolute number of monocytes (MONO#) (P=0.0050, r=0.2968), the absolute number of basophils (BASO#) (P=0.0213, r=0.2451), the red blood cell distribution width-coefficient (RDW-CV) (P=0.0136, r=0.2651), suggesting poor prognosis in anemic TB patients. Anemia is a risk factor for lung injury in TB patients. Inflammatory factors and inflammatory cells are increased during treatment in A-TB patients.
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DOI：
10.1590/s1806-37132014000400008
发表时间：
2014-07
期刊：
Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia
影响因子：
--
作者：
Oliveira MG;Delogo KN;Oliveira HM;Ruffino-Netto A;Kritski AL;Oliveira MM
通讯作者：
Oliveira MM
影响因子：
4.7
作者：
Gelaw Y;Getaneh Z;Melku M
通讯作者：
Melku M
影响因子：
3.7
作者：
Nagu, Tumaini J.;Spiegelman, Donna;Mugusi, Ferdinand
通讯作者：
Mugusi, Ferdinand
DOI：
10.1097/01.qai.0000166374.16222.a2
发表时间：
2005-10-01
影响因子：
3.6
作者：
O'Brien, ME;Kupka, R;Fawzi, WW
通讯作者：
Fawzi, WW
新发现结核病肺部病变严重程度的性别差异与年龄相关
影响因子：
3.9
作者：
Chu, Yue;Soodeen-Lalloo, Adiilah K.;Feng, Yonghong
通讯作者：
Feng, Yonghong