Anemia as a risk factor for tuberculosis: a systematic review and meta-analysis.
Anemia as a risk factor for tuberculosis: a systematic review and meta-analysis.
复制标题
贫血是结核病的危险因素：一项系统回顾和荟萃分析。
DOI：
10.1186/s12199-020-00931-z
复制
发表时间：
2021-01-23
影响因子：
4.7
通讯作者：
Melku M
中科院分区：
文献类型：
--
作者：
Gelaw Y;Getaneh Z;Melku M
结核病是由结核分枝杆菌引起的主要公共卫生问题，主要发生在社会经济地位低下的人群中。它是第二个最常见的传染病死亡原因。结核病成为贫血患者的双重负担。贫血通过降低免疫水平增加了个体对包括结核病在内的传染病的易感性。因此，本研究的目的是确定贫血是否是结核病的危险因素。使用以下MeSH术语在PubMed、Google Scholar、EMBASE和科克伦图书馆等电子数据库中检索相关已发表文章：风险因素、预测因子、结核病、TB、贫血、贫血、血红蛋白、Hgb和Hb。纳入英文文章、对贫血患者结核病发病率/患病率进行的观察性研究或将贫血作为结核病风险因素的论文。从符合入选标准的研究中，提取第一作者姓名、发表年份、研究领域、样本量和参与者年龄、研究设计和结核性贫血的效果测量。使用Microsoft Excel输入数据，并导出至Stata版本11进行分析。应用随机效应模型估计合并OR和HR以及95% CI。异质性来源采用科克伦I-squared统计进行检验。使用Egger检验统计量评估发表偏倚。共有17篇文章，215，294名研究参与者被纳入分析。贫血患者患结核病的几率是非贫血患者的3.56倍（95%CI 2.53-5.01）。队列研究显示，贫血患者中结核病的HR是非贫血患者的2.01倍（95%CI 1.70-2.37）。结核病的风险也随着贫血严重程度的增加而增加（轻度、中度和重度贫血的HR分别为1.37（95% CI 0.92-2.05）、2.08（95% CI 1.14-3.79）和2.66（95% CI 1.71-4.13））。根据目前的系统评价和荟萃分析，我们可以得出结论，贫血是结核病的危险因素。因此，应在社区开展贫血筛查、早期诊断和治疗，以减轻结核病的负担。
Tuberculosis is a major public health problem caused by Mycobacterium tuberculosis, occurring predominantly in population with low socioeconomic status. It is the second most common cause of death from infectious diseases. Tuberculosis becomes a double burden among anemic patients. Anemia increases an individual’s susceptibility to infectious diseases including tuberculosis by reducing the immunity level. Therefore, the purpose of this study was to determine whether anemia is a risk factor for tuberculosis. Relevant published articles were searched in electronic databases like PubMed, Google Scholar, EMBASE, and Cochrane Library using the following MeSH terms: risk factor, predictors, tuberculosis, TB, Anaemia, Anemia, hemoglobin, Hgb, and Hb. Articles written in the English, observational studies conducted on the incidence/prevalence of tuberculosis among anemic patients, or papers examined anemia as risk factors for tuberculosis were included. From those studies meeting eligibility criteria, the first author’s name, publication year, study area, sample size and age of participants, study design, and effect measure of anemia for tuberculosis were extracted. The data were entered using Microsoft Excel and exported to Stata version 11 for analysis. The random-effects model was applied to estimate the pooled OR and HR, and 95% CI. The sources of heterogeneity were tested by Cochrane I-squared statistics. The publication bias was assessed using Egger’s test statistics. A total of 17 articles with a 215,294 study participants were included in the analysis. The odd of tuberculosis among anemic patients was 3.56 (95% CI 2.53–5.01) times higher than non-anemic patients. The cohort studies showed that the HR of tuberculosis was 2.01 (95% CI 1.70–2.37) times higher among anemic patients than non-anemic patients. The hazard of tuberculosis also increased with anemia severity (HR 1.37 (95% CI 0.92–2.05), 2.08 (95% CI 1.14–3.79), and 2.66 (95% CI 1.71–4.13) for mild, moderate, and severe anemia, respectively). According to the current systematic review and meta-analysis, we can conclude that anemia was a risk factor for tuberculosis. Therefore, anemia screening, early diagnose, and treatment should be provoked in the community to reduce the burden of tuberculosis.
登录
查看更多内容
艾滋病毒患者的结核病的发病率和危险因素：来自巴西市的艾滋病毒转诊卫生中心的队列。
影响因子：
3.7
作者：
Batista Jd;de Albuquerque Mde F;Maruza M;Ximenes RA;Santos ML;Montarroyos UR;de Barros Miranda-Filho D;Lacerda HR;Rodrigues LC
通讯作者：
Rodrigues LC
DOI：
10.4103/0976-9668.127317
发表时间：
2014-01
期刊：
Journal of natural science, biology, and medicine
影响因子：
--
作者：
Das I;Saha K;Mukhopadhyay D;Roy S;Raychaudhuri G;Chatterjee M;Mitra PK
通讯作者：
Mitra PK
影响因子：
4.7
作者：
El Bishlawy, IM
通讯作者：
El Bishlawy, IM
影响因子：
3.2
作者：
Erkurt, Mehmet Ali;Aydogdu, Ismet;Sonmez, Ahmet
通讯作者：
Sonmez, Ahmet
影响因子：
3.7
作者：
Chu, Kuo-An;Hsu, Chun-Hsiang;Wei, James Cheng-Chung
通讯作者：
Wei, James Cheng-Chung