A Pilot Study Exploring the Mechanisms Involved in the Longitudinal Propagation of Acute Aortic Dissection through Computational Fluid Dynamic Analysis
A Pilot Study Exploring the Mechanisms Involved in the Longitudinal Propagation of Acute Aortic Dissection through Computational Fluid Dynamic Analysis
复制标题
通过计算流体动力学分析探索急性主动脉夹层纵向传播机制的初步研究
DOI：
10.1159/000358041
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发表时间：
2014-04
期刊：
影响因子：
1.9
通讯作者：
Jing, Zaiping
中科院分区：
文献类型：
--
作者：
Teng, Zhongzhao;Gillard, Jonathan H.;Song, Runze;Jing, Zaiping
目的：本研究旨在阐明急性 B 型主动脉夹层纵向传播所涉及的潜在血流动力学机制。方法：根据 3 例患者的计算机断层扫描图像重建三维患者特定主动脉几何形状，然后使用有限元分析模型进行计算流体动力学分析。重建了三个模型；正常主动脉模型（来自健康志愿者）、内脏受累模型（来自内脏动脉受累的患者）和进展模型（来自入院时内脏动脉完好的患者）。对所有三个模型中的壁压力分布进行了分析。结果：在心动周期的收缩期，真腔内主动脉壁压力从近端到远端下降。在所有三个模型中都观察到了这种压力梯度。在内脏受累模型中的假腔中看到较温和的压力梯度，而在进展模型中假腔中的压力几乎保持恒定。真腔和假腔中压力梯度的不同步导致两个腔之间的压力不平衡。结论：腔间压差可能是真腔受压和主动脉壁劈裂力的影响因素，导致夹层纵向扩展。
Objective: This study sought to elucidate the underlying hemodynamic mechanisms involved in the longitudinal propagation of acute, type-B aortic dissections. Methods: Three-dimensional patient-specific aortic geometry was reconstructed from computed tomography images of 3 cases, followed by computational fluid dynamic analysis using finite-element analysis modeling. Three models were reconstructed; the normal-aortic model (from a healthy volunteer), the visceral-involvement model (from a patient whose visceral arteries were involved) and the progression model (from a patient whose visceral arteries were intact at admission). Wall pressure distribution was analyzed in all three models. Results: In the systolic phase of a cardiac cycle, the wall pressure dropped from the proximal to the distal aorta within the true lumen. This pressure gradient was observed in all three models. A milder pressure gradient was seen in the false lumen in the visceral-involvement model, whereas the pressure in the false lumen remained almost constant in the progression model. The dyssynchrony of the pressure gradients in the true and false lumens caused an imbalance in pressure between the two lumens. Conclusion: The interluminal pressure differential may be a contributing factor in the compression of the true lumen and the cleavage force of the aortic wall, leading to the longitudinal propagation of the dissection.
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影响因子：
2.4
作者：
Tse, Kwong Ming;Chiu, Peixuan;Ho, Pei
通讯作者：
Ho, Pei
影响因子：
0.9
作者：
Karmonik, Christof;Bismuth, Jean;Lumsden, Alan B.
通讯作者：
Lumsden, Alan B.
DOI：
10.1016/j.yvas.2012.03.023
发表时间：
2012
期刊：
Yearbook of Vascular Surgery
影响因子：
--
作者：
B. Starnes
通讯作者：
B. Starnes
DOI：
10.1016/s0090-3671(10)79854-2
发表时间：
2010
期刊：
Yearbook of Surgery
影响因子：
--
作者：
T. Huber
通讯作者：
T. Huber
影响因子：
3.7
作者：
J. M. Stewart
通讯作者：
J. M. Stewart