The behavioral and neural effects of parietal theta burst stimulation on the grasp network are stronger during a grasping task than at rest.
The behavioral and neural effects of parietal theta burst stimulation on the grasp network are stronger during a grasping task than at rest.
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DOI：
10.3389/fnins.2023.1198222
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发表时间：
2023
影响因子：
4.3
通讯作者：
Vesia, Michael
中科院分区：
文献类型：
--
作者：
Goldenkoff, Elana R.;Deluisi, Joseph A.;Destiny, Danielle P.;Lee, Taraz G.;Michon, Katherine J.;Brissenden, James A.;Taylor, Stephan F.;Polk, Thad A.;Vesia, Michael
关键词：
重复经颅磁刺激（TMS）被广泛应用于神经科学和临床环境来调节人类皮层活动。经颅磁刺激对神经活动的影响取决于刺激时特定神经群的兴奋性。因此，刺激时的大脑状态可能会影响重复性经颅磁刺激对远端大脑活动和相关行为的持续影响。我们对后顶叶皮质（PPC）中与抓握控制相关的区域进行间歇性θ波爆发刺激（iTBS），以评估刺激与大脑状态之间的相互作用。通过两个实验，我们证明了运动皮层活动和运动表现对状态依赖性顶叶刺激的直接反应。我们随机将72名健康成人受试者分为三个经颅磁刺激干预组，随后进行经颅磁刺激电生理测量和行为测量。第一组参与者在执行抓取任务的同时接受iTBS到PPC。第二组的参与者在无任务的休息状态下接受iTBS到PPC。第三组参与者在执行抓取任务的同时接受皮层抓取网络外的顶叶区域的iTBS。我们比较了三个刺激组在每次干预一小时内运动皮质兴奋性和运动表现的变化。我们发现，与休息时的刺激相比，在激活皮层抓取网络的行为操作过程中，顶叶刺激增加了下游运动皮层的兴奋性，并改善了运动表现。我们的结论是，在脑刺激过程中，用行为任务限制大脑状态有可能优化调节运动过程的皮质回路机制的可塑性诱导。
Repetitive transcranial magnetic stimulation (TMS) is widely used in neuroscience and clinical settings to modulate human cortical activity. The effects of TMS on neural activity depend on the excitability of specific neural populations at the time of stimulation. Accordingly, the brain state at the time of stimulation may influence the persistent effects of repetitive TMS on distal brain activity and associated behaviors. We applied intermittent theta burst stimulation (iTBS) to a region in the posterior parietal cortex (PPC) associated with grasp control to evaluate the interaction between stimulation and brain state. Across two experiments, we demonstrate the immediate responses of motor cortex activity and motor performance to state-dependent parietal stimulation. We randomly assigned 72 healthy adult participants to one of three TMS intervention groups, followed by electrophysiological measures with TMS and behavioral measures. Participants in the first group received iTBS to PPC while performing a grasping task concurrently. Participants in the second group received iTBS to PPC while in a task-free, resting state. A third group of participants received iTBS to a parietal region outside the cortical grasping network while performing a grasping task concurrently. We compared changes in motor cortical excitability and motor performance in the three stimulation groups within an hour of each intervention. We found that parietal stimulation during a behavioral manipulation that activates the cortical grasping network increased downstream motor cortical excitability and improved motor performance relative to stimulation during rest. We conclude that constraining the brain state with a behavioral task during brain stimulation has the potential to optimize plasticity induction in cortical circuit mechanisms that mediate movement processes.
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影响因子：
9.2
作者：
Bunday, Karen L.;Perez, Monica A.
通讯作者：
Perez, Monica A.
影响因子：
3.7
作者：
Premji A;Rai N;Nelson A
通讯作者：
Nelson A
影响因子：
1.1
作者：
Chen, Robert;Udupa, Kaviraja
通讯作者：
Udupa, Kaviraja
顶壁TMS对体感觉反应的半球间影响直接与并发的TMS-FMRI证实。
DOI：
10.1523/jneurosci.3043-08.2008
发表时间：
2008-12-03
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Blankenburg F;Ruff CC;Bestmann S;Bjoertomt O;Eshel N;Josephs O;Weiskopf N;Driver J
通讯作者：
Driver J
影响因子：
2
作者：
Berardelli, A;Inghilleri, M;Manfredi, M
通讯作者：
Manfredi, M