Genetic variants associated with longitudinal changes in brain structure across the lifespan.
Genetic variants associated with longitudinal changes in brain structure across the lifespan.
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DOI:
10.1038/s41593-022-01042-4
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发表时间:
2022-04
影响因子:
25
通讯作者:
Hulshoff Pol, Hilleke E.
中科院分区:
文献类型:
--
作者:
Brouwer, Rachel M.;Klein, Marieke;Grasby, Katrina L.;Schnack, Hugo G.;Jahanshad, Neda;Teeuw, Jalmar;Thomopoulos, Sophia I.;Sprooten, Emma;Franz, Carol E.;Gogtay, Nitin;Kremen, William S.;Panizzon, Matthew S.;Olde Loohuis, Loes M.;Whelan, Christopher D.;Aghajani, Moji;Alloza, Clara;Alanaes, Dag;Artiges, Eric;Ayesa-Arriola, Rosa;Barker, Gareth J.;Bastin, Mark E.;Blok, Elisabet;Boen, Erlend;Breukelaar, Isabella A.;Bright, Joanna K.;Buimer, Elizabeth E. L.;Bulow, Robin;Cannon, Dara M.;Ciufolini, Simone;Crossley, Nicolas A.;Damatac, Christienne G.;Dazzan, Paola;de Mol, Casper L.;de Zwarte, Sonja M. C.;Desrivieres, Sylvane;Diaz-Caneja, Covadonga M.;Doan, Nhat Trung;Dohm, Katharina;Froehner, Juliane H.;Goltermann, Janik;Grigis, Antoine;Grotegerd, Dominik;Han, Laura K. M.;Harris, Mathew A.;Hartman, Catharina A.;Heany, Sarah J.;Heindel, Walter;Heslenfeld, Dirk J.;Hohmann, Sarah;Ittermann, Bernd;Jansen, Philip R.;Janssen, Joost;Jia, Tianye;Jiang, Jiyang;Jockwitz, Christiane;Karali, Temmuz;Keeser, Daniel;Koevoets, Martijn G. J. C.;Lenroot, Rhoshel K.;Malchow, Berend;Mandl, Rene C. W.;Medel, Vicente;Meinert, Susanne;Morgan, Catherine A.;Muehleisen, Thomas W.;Nabulsi, Leila;Opel, Nils;de la Foz, Victor Ortiz-Garcia;Overs, Bronwyn J.;Paillere Martinot, Marie-Laure;Redlich, Ronny;Marques, Tiago Reis;Repple, Jonathan;Roberts, Gloria;Roshchupkin, Gennady V.;Setiaman, Nikita;Shumskaya, Elena;Stein, Frederike;Sudre, Gustavo;Takahashi, Shun;Thalamuthu, Anbupalam;Tordesillas-Gutierrez, Diana;van der Lugt, Aad;van Haren, Neeltje E. M.;Wardlaw, Joanna M.;Wen, Wei;Westeneng, Henk-Jan;Wittfeld, Katharina;Zhu, Alyssa H.;Zugman, Andre;Armstrong, Nicola J.;Bonfiglio, Gaia;Bralten, Janita;Dalvie, Shareefa;Davies, Gail;Di Forti, Marta;Ding, Linda;Donohoe, Gary;Forstner, Andreas J.;Gonzalez-Penas, Javier;Guimaraes, Joao P. O. F. T.;Homuth, Georg;Hottenga, Jouke-Jan;Knol, Maria J.;Kwok, John B. J.;Le Hellard, Stephanie;Mather, Karen A.;Milaneschi, Yuri;Morris, Derek W.;Noethen, Markus M.;Papiol, Sergi;Rietschel, Marcella;Santoro, Marcos L.;Steen, Vidar M.;Stein, Jason L.;Streit, Fabian;Tankard, Rick M.;Teumer, Alexander;van 't Ent, Dennis;van der Meer, Dennis;van Eijk, Kristel R.;Vassos, Evangelos;Vazquez-Bourgon, Javier;Witt, Stephanie H.;Adams, Hieab H. H.;Agartz, Ingrid;Ames, David;Amunts, Katrin;Andreassen, Ole A.;Arango, Celso;Banaschewski, Tobias;Baune, Bernhard T.;Belangero, Sintia I.;Bokde, Arun L. W.;Boomsma, Dorret I.;Bressan, Rodrigo A.;Brodaty, Henry;Buitelaar, Jan K.;Cahn, Wiepke;Caspers, Svenja;Cichon, Sven;Crespo-Facorro, Benedicto;Cox, Simon R.;Dannlowski, Udo;Elvsashagen, Torbjorn;Espeseth, Thomas;Falkai, Peter G.;Fisher, Simon E.;Flor, Herta;Fullerton, Janice M.;Garavan, Hugh;Gowland, Penny A.;Grabe, Hans J.;Hahn, Tim;Heinz, Andreas;Hillegers, Manon;Hoare, Jacqueline;Hoekstra, Pieter J.;Ikram, Mohammad A.;Jackowski, Andrea P.;Jansen, Andreas;Jonsson, Erik G.;Kahn, Rene S.;Kircher, Tilo;Korgaonkar, Mayuresh S.;Krug, Axel;Lemaitre, Herve;Malt, Ulrik F.;Martinot, Jean-Luc;McDonald, Colm;Mitchell, Philip B.;Muetzel, Ryan L.;Murray, Robin M.;Nees, Frauke;Nenadic, Igor;Oosterlaan, Jaap;Ophoff, Roel A.;Pan, Pedro M.;Penninx, Brenda W. J. H.;Poustka, Luise;Sachdev, Perminder S.;Salum, Giovanni A.;Schofield, Peter R.;Schumann, Gunter;Shaw, Philip;Sim, Kang;Smolka, Michael N.;Stein, Dan J.;Trollor, Julian N.;van den Berg, Leonard H.;Veldink, Jan H.;Walter, Henrik;Westlye, Lars T.;Whelan, Robert;White, Tonya;Wright, Margaret J.;Medland, Sarah E.;Franke, Barbara;Thompson, Paul M.;Hulshoff Pol, Hilleke E.
Human brain structure changes throughout our lives. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental, and neurodegenerative diseases. Here, we identified common genetic variants that affect rates of brain growth or atrophy, in the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. Longitudinal MRI data from 15,640 individuals were used to compute rates of change for 15 brain structures. The most robustly identified genes GPR139, DACH1 and APOE are associated with metabolic processes. We demonstrate global genetic overlap with depression, schizophrenia, cognitive functioning, insomnia, height, body mass index and smoking. Gene-set findings implicate both early brain development and neurodegenerative processes in the rates of brain changes. Identifying variants involved in structural brain changes may help to determine biological pathways underlying optimal and dysfunctional brain development and ageing.
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影响因子:
64.8
作者:
Elliott LT;Sharp K;Alfaro-Almagro F;Shi S;Miller KL;Douaud G;Marchini J;Smith SM
通讯作者:
Smith SM
影响因子:
30.8
作者:
Das, Sayantan;Forer, Lukas;Schoenherr, Sebastian;Sidore, Carlo;Locke, Adam E.;Kwong, Alan;Vrieze, Scott I.;Chew, Emily Y.;Levy, Shawn;McGue, Matt;Schlessinger, David;Stambolian, Dwight;Loh, Po-Ru;Iacono, William G.;Swaroop, Anand;Scott, Laura J.;Cucca, Francesco;Kronenberg, Florian;Boehnke, Michael;Abecasis, Goncalo R.;Fuchsberger, Christian
通讯作者:
Fuchsberger, Christian
影响因子:
30.8
作者:
Bulik-Sullivan, Brendan K.;Loh, Po-Ru;Finucane, Hilary K.;Ripke, Stephan;Yang, Jian;Patterson, Nick;Daly, Mark J.;Price, Alkes L.;Neale, Benjamin M.
通讯作者:
Neale, Benjamin M.
影响因子:
7.7
作者:
Fjell AM;Grydeland H;Wang Y;Amlien IK;Bartres-Faz D;Brandmaier AM;Düzel S;Elman J;Franz CE;Håberg AK;Kietzmann TC;Kievit RA;Kremen WS;Krogsrud SK;Kühn S;Lindenberger U;Macía D;Mowinckel AM;Nyberg L;Panizzon MS;Solé-Padullés C;Sørensen Ø;Westerhausen R;Walhovd KB
通讯作者:
Walhovd KB
DOI:
10.1126/science.1262110
发表时间:
2015-05-08
期刊:
Science (New York, N.Y.)
影响因子:
--
作者:
GTEx Consortium
通讯作者:
GTEx Consortium