Pagliaccio, a member of the Eph family of receptor tyrosine kinase genes, has localized expression in a subset of neural crest and neural tissues in Xenopus laevis embryos

Pagliaccio, a member of the Eph family of receptor tyrosine kinase genes, has localized expression in a subset of neural crest and neural tissues in Xenopus laevis embryos
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Pagliaccio 是受体酪氨酸激酶基因 Eph 家族的成员,在非洲爪蟾胚胎的神经嵴和神经组织的子集中表达

DOI:
10.1016/0925-4773(94)90072-8
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发表时间:
1994
影响因子:
2.6
通讯作者:
T. Sargent
T. Sargent
中科院分区:
生物学4区
文献类型:
--
作者:
R. Winning;T. Sargent

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颅神经嵴细胞起源于胚胎头部的神经褶皱,并分化产生颅骨的大部分软骨和骨骼以及几个颅神经的体感神经节以及其他组织。由于对这些细胞测定的分子基础知之甚少,我们已经开始寻找参与颅神经嵴信号转导的分子。从爪蟾左颅神经嵴 cDNA 库中,我们克隆了编码假定受体酪氨酸激酶的 cDNA,我们将其称为 Pagliaccio(Pag)。PagRNA 短暂存在于内脏弓 3 中,可能代表该组织中的神经嵴细胞。Pagis 也在前脑、后脑的菱形节 r3 和 r5 以及中脑中表达。 原发性。基于这种局部表达,我们推测Pag可能在颅神经嵴和其他组织的分化中发挥作用。
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碱性 FGF 和 TGF-β 1 影响禽类胚胎神经嵴衍生细胞的黑素生成。
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