Characterizing Trends in Synthetic Cannabinoid Receptor Agonist Use from Patient Clinical Evaluations during Medical Toxicology Consultation.
Characterizing Trends in Synthetic Cannabinoid Receptor Agonist Use from Patient Clinical Evaluations during Medical Toxicology Consultation.
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DOI：
10.1080/02791072.2020.1851826
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发表时间：
2021-07
影响因子：
2.8
通讯作者：
Carlson R
中科院分区：
文献类型：
--
作者：
Tebo C;Mazer-Amirshahi M;Wax P;Campleman S;Boyer E;Brent J;Sheth A;Daniuaityte R;Carlson R
合成大麻素受体激动剂（synthetic cannabinoid receptor agonists，SCRAs）是一类新的化合物，具有深刻的精神活性作用和潜在的毒性。本研究采用定性访谈与接受医学毒理学咨询的个人的SCRA滥用模式的特点。疑似暴露于新型精神活性物质的患者在接受紧急护理时接受了医学毒理学家的访谈。研究者收集了临床和定性数据，包括与精神活性物质使用相关的知识、态度、信念和实践。通过确定主题对答复进行分类，并生成统计数据以描述使用模式。总体而言，在登记研究中输入的124例使用新型精神活性物质的病例中，69%（86）与暴露于SCRA相关。大多数患者（68.8%）在发作前至少使用过一次SCRA。47.7%的人认为SCRA非常容易获得，44.2%的人报告支付这些物质，而32.6%的人免费获得。近一半（48.8%）的患者报告他们使用的主要原因是获得高;一小部分使用SCRA以避免在药物筛查中检测阳性（6.9%）或作为大麻的替代品（4.6%）。调查结果表明，一个独立和稳定的文化正在发展周围的使用SCRA分开，他们的吸引力作为一个“不可检测”的替代大麻。
Synthetic cannabinoid receptor agonists (SCRAs) are a new class of compounds with profound psychoactive effects and potential toxicity. This study characterizes patterns in SCRA abuse using qualitative interviews with individuals receiving medical toxicology consultation. Patients with suspected exposure to a new psychoactive substance were interviewed by medical toxicologists upon presentation for acute care. Investigators collected clinical and qualitative data including knowledge, attitudes, beliefs, and practices related to psychoactive substance use. Responses were categorized by identifying themes, and statistics were generated to describe patterns of use. Overall, 69% (86) of the 124 cases of novel psychoactive substance use entered into the registry were associated with exposure to SCRAs. Most patients (68.8%) had used SCRAs at least once before the presenting episode. 47.7% considered SCRAs to be very easy to obtain, and 44.2% reported paying for the substances while 32.6% acquired it for free. Nearly half (48.8%) of patients reported their primary reason for use was to get high; a small proportion used SCRAs to avoid testing positive on drug screening (6.9%) or as an alternative to marijuana (4.6%). Findings suggest an independent and stable culture is developing around the use of SCRAs separate from their appeal as an “undetectable” alternative to marijuana.
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通讯作者：
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