Age-dependent mortality in the pilocarpine model of status epilepticus.
Age-dependent mortality in the pilocarpine model of status epilepticus.
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DOI：
10.1016/j.neulet.2009.02.035
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发表时间：
2009-04-10
影响因子：
2.5
通讯作者：
DeLorenzo RJ
中科院分区：
文献类型：
--
作者：
Blair RE;Deshpande LS;Holbert WH 2nd;Churn SB;DeLorenzo RJ
癫痫持续状态 (SE) 是一种急性神经急症，具有显着的发病率和死亡率。年龄已被证明是决定 SE 术后结果的关键因素。通过开发动物模型来研究这种情况，了解随着年龄增长死亡率增加的原因，将在研究限制 SE 引起的死亡率的机制中发挥重要作用。在这里，我们使用毛果芸香碱诱导 5 至 28 周龄的大鼠发生 SE。与人类临床研究类似，我们观察到年龄是 SE 后死亡率的重要预测因素。虽然 5 周龄动物中没有观察到死亡，但 SE 引起的死亡率随着年龄的增长而逐渐增加，在 28 周龄动物中达到 90%。动物的年龄和 SE 的严重程度之间没有相关性。随着年龄的增加，SE 发病后死亡发生得更早。这些结果表明，毛果芸香碱诱导的大鼠 SE 提供了一个有用的模型来研究年龄依赖性 SE 诱导的死亡率，并表明使用动物模型来阐明导致 SE 诱导的死亡的机制以及开发新的治疗干预措施以预防 SE 诱导的死亡的重要性。
Status epilepticus (SE) is an acute neurological emergency associated with significant morbidity and mortality. Age has been shown to be a critical factor in determining outcome after SE. Understanding the causes of this increased mortality with aging by developing an animal model to study this condition would play a major role in studying mechanisms to limit the mortality due to SE. Here we employed pilocarpine to induce SE in rats aged between 5 to 28 weeks. Similar to clinical studies in man, we observed that age was a significant predictor of mortality following SE. While no deaths were observed in 5-week old animals, mortality due to SE increased progressively with age and reached 90% in 28-week old animals. There was no correlation between the age of animals and severity of SE. With increasing age mortality occurred earlier after the onset of SE. These results indicate that pilocarpine-induced SE in the rat provides a useful model to study age-dependent SE-induced mortality and indicates the importance of using animal models to elucidate the mechanisms contributing to SE-induced mortality and the development of novel therapeutic interventions to prevent SE-induced death.
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影响因子：
2.7
作者：
PATEL, S;MELDRUM, BS;FINE, A
通讯作者：
FINE, A
影响因子：
5.6
作者：
TOWNE, AR;PELLOCK, JM;DELORENZO, RJ
通讯作者：
DELORENZO, RJ
影响因子：
3.3
作者：
Patel, M;Li, QY
通讯作者：
Li, QY
DOI：
10.1016/0013-4694(72)90177-0
发表时间：
1972-01-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
RACINE, RJ
通讯作者：
RACINE, RJ
影响因子：
2.2
作者：
Covolan, L;Mello, LEAM
通讯作者：
Mello, LEAM