8p22-23-rs2254546 as a susceptibility locus for Kawasaki disease: a case-control study and a meta-analysis.
8p22-23-rs2254546 as a susceptibility locus for Kawasaki disease: a case-control study and a meta-analysis.
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DOI：
10.1038/srep04247
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发表时间：
2014-02-28
影响因子：
4.6
通讯作者：
Gong FQ
中科院分区：
文献类型：
--
作者：
Wang W;Lou J;Lu XZ;Qi YQ;Shen N;Zhong R;Wang YJ;Zou L;Zhang Q;Duan JY;Ke JT;Miao XP;Gong FQ
8p22–23-rs2254546 was firstly discovered to be associated with Kawasaki disease (KD) susceptibility by a genome-wide association study. However, only one Chinese replication study has been performed so far. To verify this association in another Chinese population, a hospital-based case-control study in Zhejiang province was conducted followed by an integrated meta-analysis, comprising five case-control studies of 1958 cases, 5615 controls and four transmission disequilibrium tests of 503 trios. In our case-control study, significant associations were observed between GG genotype or GG/GA genotypes of rs2254546 and increased KD risk (OR = 1.86, 95% CI = 1.01–3.41, P = 0.045; OR = 1.83, 95% CI = 1.01–3.33, P = 0.048), compared with AA genotype; however, no significant association was found in allelic model (OR = 1.20, 95% CI = 0.96–1.50, P = 0.117). The meta-analysis further revealed that the G allele was significantly associated with the increased KD risk without evidence of heterogeneity (OR = 1.55, 95% CI = 1.42–1.70, P < 0.001). In conclusion, rs2254546 polymorphism might significantly contribute to the risk of KD.
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影响因子：
3.7
作者：
Chang CJ;Kuo HC;Chang JS;Lee JK;Tsai FJ;Khor CC;Chang LC;Chen SP;Ko TM;Liu YM;Chen YJ;Hong YM;Jang GY;Hibberd ML;Kuijpers T;Burgner D;Levin M;Burns JC;Davila S;International Kawasaki Disease Genetics Consortium;Korean Kawasaki Disease Genetics Consortium;Taiwan Kawasaki Disease Genetics Consortium;Chen YT;Chen CH;Wu JY;Lee YC
通讯作者：
Lee YC
影响因子：
5.3
作者：
Kim, Jae-Jung;Hong, Young Mi;Lee, Jong-Keuk
通讯作者：
Lee, Jong-Keuk
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
4.5
作者：
Burgner D;Davila S;Breunis WB;Ng SB;Li Y;Bonnard C;Ling L;Wright VJ;Thalamuthu A;Odam M;Shimizu C;Burns JC;Levin M;Kuijpers TW;Hibberd ML;International Kawasaki Disease Genetics Consortium
通讯作者：
International Kawasaki Disease Genetics Consortium
影响因子：
3
作者：
Nicodemus KK
通讯作者：
Nicodemus KK