Host functions used by hepatitis B virus to complete its life cycle: Implications for developing host-targeting agents to treat chronic hepatitis B.
Host functions used by hepatitis B virus to complete its life cycle: Implications for developing host-targeting agents to treat chronic hepatitis B.
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乙型肝炎病毒用来完成其生命周期的宿主功能：开发针对宿主靶向剂以治疗慢性乙型肝炎的影响。
DOI：
10.1016/j.antiviral.2018.08.014
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发表时间：
2018-10
影响因子：
7.6
通讯作者：
Block TM
中科院分区：
文献类型：
--
作者：
Mitra B;Thapa RJ;Guo H;Block TM
与其他哺乳动物病毒相似，B肝炎病毒（HBV）的生命周期严重依赖于细胞（宿主）功能并受其调节。这些细胞功能通常可分为两类：（a）内在宿主限制因子和先天防御，它们必须被病毒逃避或抑制;和（B）提供病毒完成其生命周期所必需的功能的基因产物。这些功能中的一些可能适用于所有病毒，但有些可能是特定于HBV。在某些情况下，病毒对宿主功能的依赖可能远远超过宿主本身。了解哪些宿主功能调节病毒生命周期的不同步骤，可以导致新的抗病毒靶点，并有助于开发新的治疗策略，此外还可以提高对病毒发病机制的基本理解。因此，在这篇综述中，我们将讨论已知的影响HBV生命周期关键步骤的宿主因素，并进一步阐明针对宿主-HBV相互作用的治疗干预措施。
Similar to other mammalian viruses, the life cycle of hepatitis B virus (HBV) is heavily dependent upon and regulated by cellular (host) functions. These cellular functions can be generally placed in to two categories: (a) intrinsic host restriction factors and innate defenses, which must be evaded or repressed by the virus; and (b) gene products that provide functions necessary for the virus to complete its life cycle. Some of these functions may apply to all viruses, but some may be specific to HBV. In certain cases, the virus may depend upon the host function much more than does the host itself. Knowing which host functions regulate the different steps of a virus’ life cycle, can lead to new antiviral targets and help in developing novel treatment strategies, in addition to improving a fundamental understanding of viral pathogenesis. Therefore, in this review we will discuss known host factors which influence key steps of HBV life cycle, and further elucidate therapeutic interventions targeting host-HBV interactions.
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影响因子：
3.7
作者：
Bruss, V;Hagelsten, J;Galle, PR
通讯作者：
Galle, PR
影响因子：
13.5
作者：
Braconi, Chiara;Huang, Nianyuan;Patel, Tushar
通讯作者：
Patel, Tushar
DOI：
10.1002/hep.29236
发表时间：
2017-12
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Diab A;Foca A;Fusil F;Lahlali T;Jalaguier P;Amirache F;N'Guyen L;Isorce N;Cosset FL;Zoulim F;Andrisani O;Durantel D
通讯作者：
Durantel D
影响因子：
5.4
作者：
Daub, H;Blencke, S;Cotten, M
通讯作者：
Cotten, M
影响因子：
5.4
作者：
Barrasa, MI;Guo, JT;Seeger, C
通讯作者：
Seeger, C