Simian adenovirus type 35 has a recombinant genome comprising human and simian adenovirus sequences, which predicts its potential emergence as a human respiratory pathogen.
Simian adenovirus type 35 has a recombinant genome comprising human and simian adenovirus sequences, which predicts its potential emergence as a human respiratory pathogen.
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DOI：
10.1016/j.virol.2013.09.009
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发表时间：
2013-12
期刊：
影响因子：
3.7
通讯作者：
Seto, Donald
中科院分区：
文献类型：
--
作者：
Dehghan, Shoaleh;Seto, Jason;Jones, Morris S.;Dyer, David W.;Chodosh, James;Seto, Donald
出现的人类和猿猴腺病毒（HAdV）可能来自基因组重组。SAdV 35型的计算分析揭示了一个基因组，其包含一个主要来自两种猿腺病毒SAdV-B21和-B27的元件的底盘，以及与HAdV-B21和HAdV-B16共享的高序列相似性区域。虽然不能确定重组方向，但这些区域的存在表明人类先前被SAdV-B35的祖先感染，反之亦然。人类中没有这种病毒可能反映了人畜共患病的非最佳条件。在HAdV基因组中发现的关键病毒复制元件和与HAdV中的基因高度相似的基因的存在表明在人类宿主中建立的潜力。这允许预测该病毒可能是新生的人类呼吸道病原体。在使用SAdV作为人类基因递送载体时，应考虑人类和猿腺病毒基因组的重组潜力。
Emergent human and simian adenoviruses (HAdVs) may arise from genome recombination. Computational analysis of SAdV type 35 reveals a genome comprising a chassis with elements mostly from two simian adenoviruses, SAdV-B21 and -B27, and regions of high sequence similarity shared with HAdV-B21 and HAdV-B16. Although recombination direction cannot be determined, the presence of these regions suggests prior infections of humans by an ancestor of SAdV-B35, and/or vice versa. Absence of this virus in humans may reflect non-optimal conditions for zoonosis. The presence of both a critical viral replication element found in HAdV genomes and genes that are highly similar to ones in HAdVs suggest the potential to establish in a human host. This allows a prediction that this virus may be a nascent human respiratory pathogen. The recombination potential of human and simian adenovirus genomes should be considered in the use of SAdVs as vectors for gene delivery in humans.
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