Potential prescribing omissions of anti‐osteoporosis drugs is associated with rehabilitation outcomes after fragility fracture: Retrospective cohort study
Potential prescribing omissions of anti‐osteoporosis drugs is associated with rehabilitation outcomes after fragility fracture: Retrospective cohort study
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抗骨质疏松药物的潜在处方遗漏与脆性骨折后的康复结果相关：回顾性队列研究
DOI：
10.1111/ggi.14145
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发表时间：
2021
影响因子：
3.3
通讯作者：
Ogawa Sumito
中科院分区：
文献类型：
--
作者：
Shibasaki Koji;Asahi Toshiomi;Kuribayashi Mari;Tajima Yuriko;Marubayashi Miki;Iwama Risa;Akishita Masahiro;Ogawa Sumito
目的我们调查了患有脆性骨折的老年人的康复结果与多重用药、潜在不适当药物和潜在处方遗漏之间的关系。方法总共，我们回顾性登记了 217 名患有脆性骨折（髋部或椎骨）的老年人，并检查了康复结果与多重用药、潜在不适当药物和潜在处方遗漏之间的关系。多重用药被定义为五种或更多药物。潜在的不适当药物和潜在的处方遗漏分别由 Beers 标准 (2015) 和提醒治疗标准版本 2 的筛查工具定义。结果是功能独立测量增益（出院时的功能独立测量 - 入院时的功能独立测量）。结果多重回归分析显示功能独立测量增益与多药治疗（粗略：β = 0.058，P = 0.858；调整模型：β = 0.013，P = 0.869）或潜在不适当药物（粗略：β = 0.100，P = 0.144；调整模型：β）之间没有关联。 = 0.084，P = 0.260）。然而，功能独立性测量增益与潜在的处方遗漏之间存在显着相关性（粗略：β = 0.167，P = 0.014；调整模型：β = 0.180，P = 0.016）。没有潜在处方遗漏的参与者（换句话说，开了抗骨质疏松药物的参与者）比有潜在处方遗漏的参与者（换句话说，没有开抗骨质疏松药物的参与者）有更大的功能独立测量增益。结论据我们所知，这项研究是第一个报告没有潜在处方遗漏的参与者康复结果显着改善的研究。Geriatr Gerontol Int 2021; 21：386-391。
AimWe investigated the association between rehabilitation outcomes and polypharmacy, potentially inappropriate medications and potential prescribing omissions in older adults with fragility fractures.MethodsIn total, we registered 217 older adults with fragility fractures (hip or vertebral) retrospectively and examined the association between rehabilitation outcome and polypharmacy, potentially inappropriate medications and potential prescribing omissions. Polypharmacy was defined as five or more drugs. Potentially inappropriate medications and potential prescribing omissions were defined by the Beers criteria (2015) and the screening tool to alert to treatment criteria version 2, respectively. The outcome was functional independence measure gain (functional independence measure at discharge – functional independence measure at admission).ResultsMultiple regression analyses revealed no association between functional independence measure gain and polypharmacy (crude: β = 0.058,P= 0.858; adjusted model: β = 0.013,P= 0.869) or potentially inappropriate medications (crude: β = 0.100,P= 0.144; adjusted model: β = 0.084,P= 0.260). However, there was a significant association between functional independence measure gain and potential prescribing omissions (crude: β = 0.167,P= 0.014; adjusted model: β = 0.180,P= 0.016). Participants without potential prescribing omissions (in other words, participants who were prescribed anti‐osteoporosis drugs) had a greater functional independence measure gain than participants with potential prescribing omissions (in other words, those that were not prescribed anti‐osteoporosis drugs).ConclusionTo the best of our knowledge, this study is the first to report that participants without potential prescribing omissions had significantly improved rehabilitation outcomes.Geriatr Gerontol Int 2021; 21: 386–391.
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影响因子：
4.7
作者：
Kose E;Maruyama R;Okazoe S;Hayashi H
通讯作者：
Hayashi H
DOI：
10.1093/gerona/glx074
发表时间：
2018-01-01
影响因子：
5.1
作者：
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通讯作者：
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DOI：
--
发表时间：
2007
期刊：
The New Zealand medical journal
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影响因子：
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作者：
Gray, Shelly L.;LaCroix, Andrea Z.;Larson, Joseph;Robbins, John;Cauley, Jane A.;Manson, JoAnn E.;Chen, Zhao
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DOI：
10.1097/phm.0b013e31805b7e20
发表时间：
2007-06-01
影响因子：
3
作者：
Kiebzak, Gary M.;Moore, Nicole L.;Kevorkian, C. George
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Kevorkian, C. George