Regulation of microRNAs in cancer metastasis.
Regulation of microRNAs in cancer metastasis.
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DOI：
10.1016/j.bbcan.2014.02.002
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发表时间：
2014-04
影响因子：
11.2
通讯作者：
Ghobrial, Irene M.
中科院分区：
文献类型：
--
作者：
Bouyssou, Juliette M. C.;Manier, Salomon;Daisy Huynh;Issa, Samar;Roccaro, Aldo M.;Ghobrial, Irene M.
转移是一种在确定癌症患者预后方面至关重要的现象，并且通常是癌症相关死亡率的原因。已知克隆细胞从其原发肿瘤部位扩散并定殖于远处组织，从而产生转移性病变需要几个步骤。因此，研究调节这一过程的分子因子可能会为开发有效的治疗反应提供有益的见解。最近的证据表明microRNA（miRNAs）在调节实体瘤转移过程中的作用。miRNA是小的调节性非编码RNA，其结合特异性靶mRNA，导致翻译抑制。已知miRNA作为基因表达的负调节剂，并且参与生理条件下和疾病（例如肿瘤）期间的生物过程（包括细胞生长、分化和凋亡）的调节。在肿瘤发生的特定领域，miRNA在介导肿瘤发生和促进肿瘤进展中起重要作用，这是由于它们能够调节上皮向间质转化（EMT）和其他一系列促进转移形成的事件。miRNA在癌症发展中的作用已被广泛研究，并有助于阐明诸如癌基因、肿瘤抑制因子和癌症相关蛋白表达变化等事件。本文综述了miRNAs在肿瘤转移过程中的作用机制。
Metastasis is a phenomenon of crucial importance in defining prognosis in patients with cancer and is often responsible for cancer-related mortality. It is known that several steps are necessary for clonal cells to disseminate from their primary tumor site and colonize distant tissues, thus originating metastatic lesions. Therefore, investigating the molecular actors regulating this process may provide helpful insights in the development of efficient therapeutic responses. Recent evidences have indicated the role of microRNAs (miRNAs) in modulating the metastatic process in solid tumors. miRNAs are small regulatory non-coding RNAs that bind specific target mRNAs, leading to translational repression. miRNAs are known to act as negative regulators of gene expression and are involved in the regulation of biological processes, including cell growth, differentiation and apoptosis, both in physiological conditions and during diseases, such as tumors. In the specific field of tumorigenesis, miRNAs play an important role in mediating oncogenesis and favoring tumor progression, as a result of their ability to modulate epithelial-to-mesenchymal transition (EMT) and other series of events facilitating the formation of metastasis. The role of miRNAs in cancer development has been widely studied and has helped elucidate events such as the change in expression of oncogenes, tumor-suppressors and cancer-related proteins. This review focuses on the mechanisms underlying the role of miRNAs as part of the metastatic process.
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影响因子：
3.7
作者：
Boominathan L
通讯作者：
Boominathan L
影响因子：
4.7
作者：
Chen DL;Wang DS;Wu WJ;Zeng ZL;Luo HY;Qiu MZ;Ren C;Zhang DS;Wang ZQ;Wang FH;Li YH;Kang TB;Xu RH
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11.2
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4
作者：
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11.2
作者：
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通讯作者：
Goodall, Gregory J.