Microbiota-Associated Therapy for Non-Alcoholic Steatohepatitis-Induced Liver Cancer: A Review.
Microbiota-Associated Therapy for Non-Alcoholic Steatohepatitis-Induced Liver Cancer: A Review.
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DOI：
10.3390/ijms21175999
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发表时间：
2020-08-20
影响因子：
5.6
通讯作者：
Wu MS
中科院分区：
文献类型：
--
作者：
Chen YH;Wu WK;Wu MS
尽管迄今为止医学的进步有助于控制许多疾病，但癌症治疗仍然面临着一些挑战。肝细胞癌（HCC）的病因是多因素的。近年来，非酒精性脂肪性肝病（NAFLD）被认为是HCC的重要危险因素。根据组织病理学特征，NAFLD可分为非酒精性单纯性脂肪肝（NAFL）和非酒精性脂肪性肝炎（NASH）。最近，研究表明肠道微生物群与NAFLD和HCC相关。因此，在这篇综述中，我们讨论了肠道微生物群相关机制，包括生态失调和肠道屏障功能，以及肠道微生物群衍生的代谢产物对NAFLD和HCC发病机制的影响，以及NAFLD和HCC的潜在治疗策略。随着对肠道微生物群组成和功能的更好了解，可以开发出针对常见肝脏疾病的新的和改进的诊断、预后和治疗策略。
Even though advancement in medicine has contributed to the control of many diseases to date, cancer therapy continues to pose several challenges. Hepatocellular carcinoma (HCC) etiology is multifactorial. Recently, non-alcoholic fatty liver disease (NAFLD) has been considered as an important risk factor of HCC. NAFLD can be divided into non-alcoholic simple fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH) based on histopathological features. Recently, studies have indicated that the gut microbiota is associated with NAFLD and HCC. Therefore, in this review, we have discussed the effects of gut microbiota-related mechanisms, including dysbiosis and gut barrier function, and gut microbiota-derived metabolites on NAFLD and HCC pathogenesis and the potential therapeutic strategies for NAFLD and HCC. With a better understanding of the gut microbiota composition and function, new and improved diagnostic, prognostic, and therapeutic strategies for common liver diseases can be developed.
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影响因子：
3.7
作者：
Baker SS;Baker RD;Liu W;Nowak NJ;Zhu L
通讯作者：
Zhu L
DOI：
10.5005/jp-journals-10018-1226
发表时间：
2017-01
期刊：
Euroasian journal of hepato-gastroenterology
影响因子：
--
作者：
Abdel Monem SM
通讯作者：
Abdel Monem SM
影响因子：
64.8
作者：
Devkota, Suzanne;Wang, Yunwei;Musch, Mark W.;Leone, Vanessa;Fehlner-Peach, Hannah;Nadimpalli, Anuradha;Antonopoulos, Dionysios A.;Jabri, Bana;Chang, Eugene B.
通讯作者：
Chang, Eugene B.
影响因子：
4.8
作者：
Brown, AJ;Goldsworthy, SM;Dowell, SJ
通讯作者：
Dowell, SJ
影响因子：
13.5
作者：
Bajaj, Jasmohan S.;Kakiyama, Genta;Gillevet, Patrick M.
通讯作者：
Gillevet, Patrick M.