Widespread nociceptive maps in the human neonatal somatosensory cortex
Widespread nociceptive maps in the human neonatal somatosensory cortex
复制标题
人类新生儿体感皮层中广泛存在的伤害性地图
DOI:
10.1101/2021.07.29.454164
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发表时间:
2021
期刊:
影响因子:
--
通讯作者:
Jones L
中科院分区:
文献类型:
--
作者:
Jones L
Topographic cortical maps are essential for spatial localisation of sensory stimulation and generation of appropriate task-related motor responses. Somatosensation and nociception are finely mapped and aligned in the adult somatosensory (S1) cortex, but in infancy, when pain behaviour is disorganised and poorly directed, nociceptive maps may be less refined. We compared the topographic pattern of S1 activation following noxious (clinically required heel lance) and innocuous (touch) mechanical stimulation of the same skin region in newborn infants (n= 32) using multioptode functional near-infrared spectroscopy (fNIRS). Within S1 cortex, touch and lance of the heel elicit localised, partially overlapping increases in oxygenated haemoglobin concentration (Δ [HbO]), but while touch activation was restricted to the heel area, lance activation extended into cortical hand regions. The data reveals a widespread cortical nociceptive map in infant S1, consistent with their poorly directed pain behaviour.
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