Widespread nociceptive maps in the human neonatal somatosensory cortex

Widespread nociceptive maps in the human neonatal somatosensory cortex
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人类新生儿体感皮层中广泛存在的伤害性地图

DOI:
10.1101/2021.07.29.454164
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发表时间:
2021
期刊:
--
影响因子:
--
通讯作者:
Jones L
Jones L
中科院分区:
--
文献类型:
--
作者:
Jones L

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地形皮层地图是必不可少的空间定位的感觉刺激和产生适当的任务相关的运动反应。躯体感觉和伤害感受在成人躯体感觉(S1)皮层中被精细地映射和对齐,但在婴儿期,当疼痛行为紊乱且定向不良时,伤害感受地图可能不那么精细。我们比较了地形图模式的S1激活后,有毒的(临床上需要的脚跟长矛)和无害的(触摸)机械刺激新生儿(n= 32)相同的皮肤区域使用多光电功能近红外光谱(fNIRS)。在S1皮质内,触觉和足跟针刺引起局部的、部分重叠的氧合血红蛋白浓度(Δ [HbO])增加,但触觉激活仅限于足跟区域,针刺激活延伸到皮质手区域。这些数据揭示了一个广泛的皮层伤害性地图在婴儿S1,与他们的不良定向疼痛行为。
Topographic cortical maps are essential for spatial localisation of sensory stimulation and generation of appropriate task-related motor responses. Somatosensation and nociception are finely mapped and aligned in the adult somatosensory (S1) cortex, but in infancy, when pain behaviour is disorganised and poorly directed, nociceptive maps may be less refined. We compared the topographic pattern of S1 activation following noxious (clinically required heel lance) and innocuous (touch) mechanical stimulation of the same skin region in newborn infants (n= 32) using multioptode functional near-infrared spectroscopy (fNIRS). Within S1 cortex, touch and lance of the heel elicit localised, partially overlapping increases in oxygenated haemoglobin concentration (Δ [HbO]), but while touch activation was restricted to the heel area, lance activation extended into cortical hand regions. The data reveals a widespread cortical nociceptive map in infant S1, consistent with their poorly directed pain behaviour.
DOI: --
发表时间: 2018
期刊:
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