The emergence of somatotopic maps of the body in S1 in rats: the correspondence between functional and anatomical organization.
The emergence of somatotopic maps of the body in S1 in rats: the correspondence between functional and anatomical organization.
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DOI：
10.1371/journal.pone.0032322
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Krubitzer LA
中科院分区：
文献类型：
--
作者：
Seelke AM;Dooley JC;Krubitzer LA
我们所知道的关于大脑皮层地图发育和可塑性的大部分来自对小鼠和大鼠的研究，对于体感皮质，几乎完全来自胡须主导的后内侧桶状区域。胡须是小鼠和大鼠的主要效应器官，其在皮质和皮质下通路中的表达是小鼠啮齿动物高度衍生的特征。因此，这种专门的解剖学组织可能并不代表总体上的躯体感觉皮质，特别是对于利用身体其他部位作为主要效应器官的物种，如灵长类动物的手。出于这些原因，我们使用电生理记录技术研究了发育中的大鼠全身地图的出现。在P5、P10、P15、P20和成年大鼠，在每只动物的S1内侧部分进行多次记录。随后，基于各种组织学染色，这些功能图与S1的解剖切片相关联。我们发现，在出生后早期(P5)，内侧S1几乎完全由触须的代表组成。在P10时，出现了包括后肢和前肢在内的其他身体部位，尽管这些没有按地形图组织。到P15时，随着接受野大小的减小，开始出现清晰的地形图组织。到了20岁时，身体地图就像成人一样了。这项研究首次描述了哺乳动物S1区的身体结构是如何发展的。这表明解剖图谱和功能图谱最初是不一致的，但在P15时变得紧密耦合。最后，由于桶状皮质发育的解剖学和功能特异性在出生后的生命中比身体的其他部分出现得更早，所以在研究发育过程中一般地形图的形成时，应该考虑整个初级体感皮质。
Most of what we know about cortical map development and plasticity comes from studies in mice and rats, and for the somatosensory cortex, almost exclusively from the whisker-dominated posteromedial barrel fields. Whiskers are the main effector organs of mice and rats, and their representation in cortex and subcortical pathways is a highly derived feature of murine rodents. This specialized anatomical organization may therefore not be representative of somatosensory cortex in general, especially for species that utilize other body parts as their main effector organs, like the hands of primates. For these reasons, we examined the emergence of whole body maps in developing rats using electrophysiological recording techniques. In P5, P10, P15, P20 and adult rats, multiple recordings were made in the medial portion of S1 in each animal. Subsequently, these functional maps were related to anatomical parcellations of S1 based on a variety of histological stains. We found that at early postnatal ages (P5) medial S1 was composed almost exclusively of the representation of the vibrissae. At P10, other body part representations including the hindlimb and forelimb were present, although these were not topographically organized. By P15, a clear topographic organization began to emerge coincident with a reduction in receptive field size. By P20, body maps were adult-like. This study is the first to describe how topography of the body develops in S1 in any mammal. It indicates that anatomical parcellations and functional maps are initially incongruent but become tightly coupled by P15. Finally, because anatomical and functional specificity of developing barrel cortex appears much earlier in postnatal life than the rest of the body, the entire primary somatosensory cortex should be considered when studying general topographic map formation in development.
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DOI：
10.1073/pnas.84.12.4322
发表时间：
1987-06-01
影响因子：
11.1
作者：
DAMATO, RJ;BLUE, ME;SNYDER, SH
通讯作者：
SNYDER, SH
影响因子：
2.5
作者：
BOLLES, RC;WOODS, PJ
通讯作者：
WOODS, PJ
影响因子：
64.8
作者：
CRAIR, MC;MALENKA, RC
通讯作者：
MALENKA, RC
DOI：
10.1073/pnas.88.8.2999
发表时间：
1991-04-01
影响因子：
11.1
作者：
CATALANO, SM;ROBERTSON, RT;KILLACKEY, HP
通讯作者：
KILLACKEY, HP
影响因子：
2.5
作者：
Campi, Katharine L.;Krubitzer, Leah
通讯作者：
Krubitzer, Leah