Thalamus is a common locus of reading, arithmetic, and IQ: Analysis of local intrinsic functional properties.
Thalamus is a common locus of reading, arithmetic, and IQ: Analysis of local intrinsic functional properties.
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DOI：
10.1016/j.bandl.2020.104835
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发表时间：
2020-10
影响因子：
2.5
通讯作者：
Pugh KR
中科院分区：
文献类型：
--
作者：
Koyama MS;Molfese PJ;Milham MP;Mencl WE;Pugh KR
对基本成就技能——阅读和算术——的神经成像研究通常控制智商的影响，以确定每项技能的独特神经关联。这可能低估了成绩和智商测量之间的共同因素对神经成像结果的可能影响。在这里，我们同时检查了年轻人的成就（阅读和算术）和智商测量，旨在确定其共同因素的MRI相关性。静息状态fMRI （rs-fMRI）数据分析使用两个指标评估局部本征功能特性；区域均匀性（ReHo）和分数振幅低频波动（fALFF），分别测量局部内禀功能连通性和内禀功能活性。ReHo强调，丘脑/枕状核（一个皮层下区域，暗示着选择性注意）是成就技能和智商的共同位点。更具体地说，ReHo值越高，成就和智商得分就越低。对于fALFF来说，作为背侧注意网络的一部分，左侧顶叶上小叶与阅读和智商呈正相关。总的来说，我们的研究结果强调了与注意力相关的区域，特别是丘脑/枕状核，它是与三个测试中个体表现差异相关的关键区域。丘脑/枕状核中的ReHo可以作为一种工具，用于检查阅读和算术困难共病背后的大脑机制，这可能与一般智力能力低下同时发生。
Neuroimaging studies of basic achievement skills – reading and arithmetic – often control for the effect of IQ to identify unique neural correlates of each skill. This may underestimate possible effects of common factors between achievement and IQ measures on neuroimaging results. Here, we simultaneously examined achievement (reading and arithmetic) and IQ measures in young adults, aiming to identify MRI correlates of their common factors. Resting-state fMRI (rs-fMRI) data were analyzed using two metrics assessing local intrinsic functional properties; regional homogeneity (ReHo) and fractional amplitude low frequency fluctuation (fALFF), measuring local intrinsic functional connectivity and intrinsic functional activity, respectively. ReHo highlighted the thalamus/pulvinar (a subcortical region implied for selective attention) as a common locus for both achievement skills and IQ. More specifically, the higher the ReHo values, the lower the achievement and IQ scores. For fALFF, the left superior parietal lobule, part of the dorsal attention network, was positively associated with reading and IQ. Collectively, our results highlight attention-related regions, particularly the thalamus/pulvinar as a key region related to individual differences in performance on all the three measures. ReHo in the thalamus/pulvinar may serve as a tool to examine brain mechanisms underlying a comorbidity of reading and arithmetic difficulties, which could co-occur with weakness in general intellectual abilities.
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影响因子：
3.8
作者：
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通讯作者：
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DOI：
10.1111/j.1365-2788.2010.01281.x
发表时间：
2010-05-01
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通讯作者：
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通讯作者：
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