Surveillance behavior of women with a reported family history of colorectal cancer.
Surveillance behavior of women with a reported family history of colorectal cancer.
复制标题
对有结直肠癌家族史的女性的监测行为。
作者：
Françoise Clavel;R. Joseph;Hélène Goulard
研究目的
本研究测试了有结直肠癌家族史的女性的监测行为是否与没有结直肠癌家族史的女性不同。
设计
该研究包括来自E3 N人群的72，710名受试者，这是一项队列研究，是欧洲癌症前瞻性调查的一部分，调查了女性癌症的风险因素。
结果
19.4%的家族中无CRC的女性和21.8%的家族中有一个或多个CRC的女性报告了粪便隐血试验（FOBT）（频率比值比（FOR）= 1.01; ns）。亲属关系对FOBT无影响。10.9%的家庭中没有CRC的女性报告了结肠镜检查;其频率随着家庭中受CRC影响的受试者数量的增加而增加，特别是当其涉及一级亲属时。有两个或两个以上一级亲属患有CRC的受试者结肠镜检查的频率几乎是没有任何受影响成员的受试者的四倍（FOR = 3.55; 95%CI 2.47-5.10）;与家族中没有任何受影响亲属的受试者相比，有二级受影响亲属的妇女结肠镜检查的频率增加，尽管不太明显。
结论
总之，虽然FOBT不受CRC家族史的影响，但在有家族史的女性中，筛查性结肠镜检查更常见，并且受影响亲属的亲属关系程度不同。在有一级和二级亲属的受试者中观察到的高结肠镜检查率可能是由于医生参与了筛查决策。
STUDY OBJECTIVE
The present study tested whether the surveillance behavior of women with a family history of colorectal cancer (CRC) differed from that of women without such a history.
DESIGN
The study included 72,710 subjects from the population of E3N, a cohort study, part of the European Prospective Investigation on Cancer, investigating risk factors for cancer among women.
RESULTS
Fecal occult-blood testing (FOBT) was reported by 19.4% of the women with no CRC in their family and by 21.8% of those with one or more CRC (frequency odds ratio (FOR) = 1.01; ns). The degree of kinship did not influence FOBT. Colonoscopy was reported by 10.9% of women with no CRC in their family; its frequency increased with increasing number of subjects affected by CRC in the family, in particular when it concerned first-degree relatives. Colonoscopy was reported almost four times more frequently by subjects having two or more first-degree relatives with CRC (FOR = 3.55; 95% CI 2.47-5.10) than by those without any affected member; the frequency of colonoscopy increased, though less sharply, among women with second-degree affected relatives, compared with those without any affected relative in their family.
CONCLUSION
In conclusion, whereas FOBT was unaffected by family history of CRC, screening colonoscopy was more frequent among women with a reported family history and differed with the degree of kinship of the affected relatives. The high rate of colonoscopy observed among subjects with first- and second-degree relatives is likely due to physician participation in screening decisions.
患者对自我指导的吸血试验的依从性。
影响因子：
5.1
作者：
Morrow,GR;Way,J;Hoagland,AC;Cooper,R
通讯作者：
Cooper,R