Promise of personalized omics to precision medicine.
Promise of personalized omics to precision medicine.
复制标题
DOI：
10.1002/wsbm.1198
复制
发表时间：
2013-01
影响因子：
7.9
通讯作者：
Snyder, Michael
中科院分区：
文献类型：
--
作者：
Chen, Rui;Snyder, Michael
高通量技术和计算框架的快速发展使生物系统的检查前所未有的详细。在组学水平上研究生物现象的能力反过来有望导致个性化和精准医学的重大进步。患者可以根据自己的分子特征进行治疗。个体组以及多个组的整合概况，如基因组、表观基因组、转录组、蛋白质组、代谢组、抗体组和其他组学信息，预计对健康监测、预防措施和精准医学有价值。此外，组学技术有可能使医学从传统的以诊断和治疗疾病为导向的诊断和治疗转向疾病预防和早期诊断。我们在这里讨论了系统生物学驱动的个性化医疗在现阶段的进展和挑战，以及在本综述结束时对未来个性化医疗的前瞻性看法。
The rapid development of high-throughput technologies and computational frameworks enables the examination of biological systems in unprecedented detail. The ability to study biological phenomena at omics levels in turn is expected to lead to significant advances in personalized and precision medicine. Patients can be treated according to their own molecular characteristics. Individual omes as well as the integrated profiles of multiple omes, such as the genome, the epigenome, the transcriptome, the proteome, the metabolome, the antibodyome, and other omics information are expected to be valuable for health monitoring, preventative measures, and precision medicine. Moreover, omics technologies have the potential to transform medicine from traditional symptom-oriented diagnosis and treatment of diseases towards disease prevention and early diagnostics. We discuss here the advances and challenges in systems biology-powered personalized medicine at its current stage, as well as a prospective view of future personalized health care at the end of this review.
登录
查看更多内容
影响因子：
46.9
作者：
通讯作者：
--
影响因子：
5
作者：
Berman, David M.;Bosenberg, Marcus W.;Loda, Massimo
通讯作者：
Loda, Massimo
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
64.5
作者：
Huang Y;Mucke L
通讯作者：
Mucke L
影响因子：
64.5
作者：
Ideker T;Dutkowski J;Hood L
通讯作者：
Hood L