Reproducibility of quantitative plaque measurement in advanced coronary artery disease.
Reproducibility of quantitative plaque measurement in advanced coronary artery disease.
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晚期冠状动脉疾病中定量斑块测量的可重复性。
DOI：
10.1016/j.jcct.2020.12.008
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发表时间：
2021-07
影响因子：
5.4
通讯作者：
Dey D
中科院分区：
文献类型：
--
作者：
Meah MN;Singh T;Williams MC;Dweck MR;Newby DE;Slomka P;Adamson PD;Moss AJ;Dey D
表征和量化冠状动脉疾病程度的能力有可能提高冠状动脉计算机断层血管造影的预后能力。虽然在轻度冠状动脉疾病患者中已经描述了可重复的技术，但在晚期疾病患者中尚未进行评估。20例已知有多支血管疾病的患者，每隔2周重复进行冠状动脉计算机断层扫描。由两名训练有素的观测者使用半自动软件分析冠状动脉段，以确定观测者内、观测者间和扫描间的可重复性。总共分析了149个冠状动脉段。所有斑块体积测量结果在观察者内部和观察者之间都有很好的一致性（林系数0.95 ~ 1.0）。总的斑块体积（2063±1246 mm3，平均差值为- 35.6 mm3）、非钙化斑块体积（1795±910 mm3，平均差值为- 4.3 mm3）、钙化斑块体积（298±425 mm3，平均差值为- 31.3 mm3）和低衰减斑块体积（13±13 mm3，平均差值为- 2.6 mm3）在扫描间无显著差异（P < 0.05）。扫描间一致性最高的是总的和非钙化斑块体积。钙化斑块和低衰减斑块（分别为- 236.6至174 mm3和- 15.8至10.5 mm3）具有相对较宽的95%一致性界限，反映了斑块绝对体积较低。在存在晚期冠状动脉疾病的情况下，半自动斑块定量提供了极好的再现性，特别是总的和非钙化斑块体积。该方法在评估疾病随时间的变化和优化已确诊冠状动脉疾病患者的风险分层方面具有重大潜力。原始研究：我们在一组晚期冠状动脉疾病患者中证明了计算机断层冠状动脉造影半自动斑块定量的良好再现性。在每个患者的水平上，观察者内、观察者间和扫描间的相关性对于总斑块体积和非钙化斑块体积都是极好的。斑块量化是一种评估疾病进展的可靠方法，有助于优化已确诊冠状动脉疾病患者的风险分层。
The ability to characterize and to quantify the extent of coronary artery disease has the potential to improve the prognostic capability of coronary computed tomography angiography. Although reproducible techniques have been described in those with mild coronary disease, this has yet to be assessed in patients with advanced disease. Twenty patients with known multivessel disease underwent repeated computed tomography coronary angiography, 2 weeks apart. Coronary artery segments were analysed using semi-automated software by two trained observers to determine intraobserver, interobserver and interscan reproducibility. Overall, 149 coronary arterial segments were analysed. There was excellent intraobserver and interobserver agreement for all plaque volume measurements (Lin’s coefficient 0.95 to 1.0). There were no substantial interscan differences (P>0.05 for all) for total (2063±1246 mm3, mean of differences −35.6 mm3), non-calcified (1795±910 mm3, mean of differences −4.3 mm3), calcified (298±425 mm3, mean of differences −31.3 mm3) and low-attenuation (13±13 mm3, mean of differences −2.6 mm3) plaque volumes. Interscan agreement was highest for total and noncalcified plaque volumes. Calcified and low-attenuation plaque (−236.6 to 174 mm3 and −15.8 to 10.5 mm3 respectively) had relatively wider 95% limits of agreement reflecting the lower absolute plaque volumes. In the presence of advanced coronary disease, semi-automated plaque quantification provides excellent reproducibility, particularly for total and non-calcified plaque volumes. This approach has major potential to assess change in disease over time and optimize risk stratification in patients with established coronary artery disease. Original research: We demonstrate the excellent reproducibility of semi-automated plaque quantification on computed tomography coronary angiography in a cohort of patients with advanced coronary artery disease. On a per patient level, intraobserver, interobserver and interscan correlations were excellent for total plaque volume and non-calcified plaque volume. Plaque quantification represents a robust approach for the assessment of disease progression and facilitates the optimisation of risk stratification in patients with established coronary artery disease.
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影响因子：
5.4
作者：
Ovrehus, Kristian Altern;Schuhbaeck, Annika;Dey, Damini
通讯作者：
Dey, Damini
影响因子：
24
作者：
Chang HJ;Lin FY;Lee SE;Andreini D;Bax J;Cademartiri F;Chinnaiyan K;Chow BJW;Conte E;Cury RC;Feuchtner G;Hadamitzky M;Kim YJ;Leipsic J;Maffei E;Marques H;Plank F;Pontone G;Raff GL;van Rosendael AR;Villines TC;Weirich HG;Al'Aref SJ;Baskaran L;Cho I;Danad I;Han D;Heo R;Lee JH;Rivzi A;Stuijfzand WJ;Gransar H;Lu Y;Sung JM;Park HB;Berman DS;Budoff MJ;Samady H;Shaw LJ;Stone PH;Virmani R;Narula J;Min JK
通讯作者：
Min JK
影响因子：
5.4
作者：
Cheng, Victor Y;Nakazato, Ryo;Berman, Daniel S
通讯作者：
Berman, Daniel S
脱糖苷升高患者对他汀类药物疗法的患者冠状动脉粥样硬化进展的影响：蒸发试验的最终结果。
影响因子：
39.3
作者：
Budoff MJ;Bhatt DL;Kinninger A;Lakshmanan S;Muhlestein JB;Le VT;May HT;Shaikh K;Shekar C;Roy SK;Tayek J;Nelson JR
通讯作者：
Nelson JR
影响因子：
14
作者：
Moss, Alastair J.;Dweck, Marc R.;Adamson, Philip D.
通讯作者：
Adamson, Philip D.