Beneficial effect of simvastatin and pravastatin treatment on adverse cardiac remodelling and glomeruli loss in spontaneously hypertensive rats.
Beneficial effect of simvastatin and pravastatin treatment on adverse cardiac remodelling and glomeruli loss in spontaneously hypertensive rats.
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辛伐他汀和普伐他汀治疗对自发性高血压大鼠不良心脏重塑和肾小球损失的有益作用。
DOI：
10.1042/cs20040292
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发表时间：
2005
期刊：
影响因子：
6
通讯作者：
C. Mandarim
中科院分区：
文献类型：
--
作者：
D. G. Bezerra;C. Mandarim
本研究的目的是探讨疏水性他汀类药物辛伐他汀和亲水性他汀类药物普伐他汀对SHR（自发性高血压大鼠）超负荷左心室和肾皮质重构过程的不同影响的可能性。15只SHR经口胃给予辛伐他汀、普伐他汀或安慰剂（水）治疗40天。光镜和体视学检查左心室和肾皮质。通过解剖器方法估计LV（左心室）心肌细胞核（N[cmn]）和肾小球（N[gl]）数量。他汀类药物治疗组的BP（血压）和血清三酰甘油（甘油三酯）低于未治疗对照组。与对照组相比，他汀类药物治疗组间质结缔组织的体积密度较小，心肌内动脉的长度密度以及动脉/心肌细胞比率较大。两个他汀类药物治疗组之间未观察到差异。辛伐他汀治疗组心肌细胞横截面积显著小于对照组或普伐他汀治疗组，普伐他汀治疗组小于对照组。两个他汀类药物治疗组的N[cmn]和N[gl]均大于对照组，但两个他汀类药物治疗组之间未观察到显著差异。总之，给予SHR他汀类药物辛伐他汀和普伐他汀可有效预防血压和血清甘油三酯升高，并通过预防LV肥大、增强心肌血管化、减少间质纤维化和减轻心肌细胞和肾小球损失来减轻不良心脏和肾脏重塑。
The aim of the present study was to investigate the possibility of different effects of the hydrophobic statin simvastatin and the hydrophilic statin pravastatin on the remodelling process in the overloaded left ventricle and renal cortex of SHRs (spontaneously hypertensive rats). Fifteen SHRs were treated for 40 days with simvastatin, pravastatin or placebo (water) via orogastric administration. Left ventricle and renal cortex were examined by light microscopy and stereology. LV (left ventricular) cardiomyocyte nuclei (N[cmn]) and glomeruli (N[gl]) numbers were estimated by the dissector method. BP (blood pressure) and serum triacylglycerols (triglycerides) were lower in the statin-treated groups than in the untreated control group. The volume density of the interstitial connective tissue was smaller and length density of the intramyocardial arteries, as well as the arteries/cardiomyocyte ratio, was greater in the statin-treated groups than in the control group. No difference was observed between the two statin-treated groups. The cross-sectional cardiomyocyte area was significantly smaller in the simvastatin-treated group than in the control or pravastatin-treated groups, and it was smaller in the pravastatin-treated group than in the control group. N[cmn] and N[gl] were greater in the two statin-treated groups than in the control group, but no significant difference was observed between the two statin-treated groups. In conclusion, administration of the statins simvastatin and pravastatin to SHRs effectively prevented the elevation in BP and serum triaclyglycerols, and also attenuated adverse cardiac and kidney remodelling by preventing LV hypertrophy, enhancing myocardial vascularization with the decrease in interstitial fibrosis and attenuating cardiomyocyte and glomerular loss.
影响因子：
15.9
作者：
Bowman, JC;Steinberg, SF;Buttrick, PM
通讯作者：
Buttrick, PM
影响因子：
37.8
作者：
Lefer, AM;Campbell, B;Lefer, DJ
通讯作者：
Lefer, DJ
影响因子：
20.1
作者：
Asahara, T;Masuda, H;Isner, JM
通讯作者：
Isner, JM