Nanodelivery of STING agonists against cancer and infectious diseases.
Nanodelivery of STING agonists against cancer and infectious diseases.
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DOI：
10.1016/j.mam.2021.101007
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发表时间：
2022-03
影响因子：
10.6
通讯作者：
Zhang L
中科院分区：
文献类型：
--
作者：
Zhou J;Ventura CJ;Fang RH;Zhang L
疫苗接种是一种已被广泛探索用于治疗各种疾病的方式。为了提高疫苗制剂的效力，免疫刺激佐剂已被定期开发，并且干扰素基因（STING）信号传导途径的刺激物最近已成为一个显着的治疗靶标。STING是内质网上的内源性蛋白质，其是胞质DNA的下游传感器。一旦激活，STING启动一系列细胞内信号级联，最终产生有效的I型干扰素介导的免疫应答。天然和合成激动剂都已用于刺激STING途径，但由于生物利用度低、不稳定和难以绕过质膜，它们通常局部施用。凭借出色的药代动力学特征和多功能性，纳米载体可以解决其中许多挑战并拓宽STING疫苗的应用。沿着这些路线，正在开发STING诱导纳米疫苗，以解决广泛的疾病。在这篇综述中，我们讨论了STING纳米疫苗的抗癌，抗病毒和抗菌应用的最新进展。
Vaccination is a modality that has been widely explored for the treatment of various diseases. To increase the potency of vaccine formulations, immunostimulatory adjuvants have been regularly exploited, and the stimulator of interferon genes (STING) signaling pathway has recently emerged as a remarkable therapeutic target. STING is an endogenous protein on the endoplasmic reticulum that is a downstream sensor to cytosolic DNA. Upon activation, STING initiates a series of intracellular signaling cascades that ultimately generate potent type I interferon-mediated immune responses. Both natural and synthetic agonists have been used to stimulate the STING pathway, but they are usually administered locally due to low bioavailability, instability, and difficulty in bypassing the plasma membrane. With excellent pharmacokinetic profiles and versatility, nanocarriers can address many of these challenges and broaden the application of STING vaccines. Along these lines, STING-inducing nanovaccines are being developed to address a wide range of diseases. In this review, we discuss the recent advances in STING nanovaccines for anticancer, antiviral, and antibacterial applications.
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影响因子：
7.8
作者：
Angsantikul P;Thamphiwatana S;Gao W;Zhang L
通讯作者：
Zhang L
影响因子：
4.9
作者：
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通讯作者：
Ainslie KM
DOI：
10.1084/jem.20050915
发表时间：
2005-12-19
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
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通讯作者：
Kroemer G
DOI：
10.1038/nri3921
发表时间：
2015-12
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
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影响因子：
11.4
作者：
Cavlar, Taner;Deimling, Tobias;Hornung, Veit
通讯作者：
Hornung, Veit