The Association between Diffusion MRI-Defined Infarct Volume and NIHSS Score in Patients with Minor Acute Stroke.
The Association between Diffusion MRI-Defined Infarct Volume and NIHSS Score in Patients with Minor Acute Stroke.
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DOI：
10.1111/jon.12423
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发表时间：
2017-07
期刊：
影响因子：
--
通讯作者：
Boden-Albala B
中科院分区：
文献类型：
--
作者：
Yaghi S;Herber C;Boehme AK;Andrews H;Willey JZ;Rostanski SK;Siket M;Jayaraman MV;McTaggart RA;Furie KL;Marshall RS;Lazar RM;Boden-Albala B
先前的研究表明，美国国立卫生研究院卒中量表（NIHSS）与弥散加权成像（DWI）上的卒中体积之间存在相关性；在轻度脑卒中患者中，数据更为有限。我们试图确定轻度卒中患者DWI病变体积与(1)NIHSS总评分和(2)NIHSS成分评分之间的关系。我们纳入了所有参加卒中预警信息和快速治疗研究的轻度卒中患者（NIHSS 0-5）。我们使用医学图像处理，分析和可视化（MIPAV， NIH, Version 7.1.1）计算DWI序列上的病变体积（cm3）。我们使用非参数检验来研究主要结局、DWI病变体积和预测因子（NIHSS评分及其组成部分）之间的关系。我们确定了894例出院诊断为轻度中风的患者；磁共振成像709例，DWI阳性510例。NIHSS评分与DWI病变中位体积（cm3）呈分级关系（NIHSS 0: 7.1、NIHSS 1:8 0、NIHSS 2:17 1、NIHSS 3:11 6、NIHSS 4:19 0、NIHSS 5:23 6, P < 0.01）。忽视患者（105.6 vs. 12.5, P = 0.025）、语言障碍患者（34.6 vs. 11.9, P < 0.001）和视野障碍患者（185.6 vs. 11.6, P < 0.001）的中位病变体积显著更高。NIHSS的其他成分与病变体积无关。在轻度脑卒中患者中，当使用NIHSS评分时，缺陷的性质可以改善对梗死面积的预测。这可能具有临床和治疗意义。
Prior studies have shown a correlation between the National Institutes of Health Stroke Scale (NIHSS) and stroke volume on diffusion weighted imaging (DWI); data are more limited in patients with minor stroke. We sought to determine the association between DWI lesion(s) volume and the (1) total NIHSS score and (2) NIHSS component scores in patients with minor stroke. We included all patients with minor stroke (NIHSS 0–5) enrolled in the Stroke Warning Information and Faster Treatment study. We calculated lesion(s) volume (cm3) on the DWI sequence using Medical Image Processing, Analysis, and Visualization (MIPAV, NIH, Version 7.1.1). We used nonparametric tests to study the association between the primary outcome, DWI lesion(s) volume, and the predictors (NIHSS score and its components). We identified 894 patients with a discharge diagnosis of minor stroke; 709 underwent magnetic resonance imaging and 510 were DWI positive. There was a graded relationship between the NIHSS score and median DWI lesion volume in cm3: (NIHSS 0: 7.1, NIHSS 1: 8.0, NIHSS 2: 17.1, NIHSS 3: 11.6, NIHSS 4: 19.0, and NIHSS 5: 23.6, P < .01). The median lesion volume was significantly higher in patients with neglect (105.6 vs. 12.5, P = .025), language disorder (34.6 vs. 11.9, P < .001), and visual field impairment (185.6 vs. 11.6, P < .001). Other components of the NIHSS were not associated with lesion volume. In patients with minor stroke, the nature of deficit when used with the NIHSS score can improve prediction of infarct volume. This may have clinical and therapeutic implications.
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DOI：
10.3174/ajnr.a3690
发表时间：
2013-11
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Wintermark M;Sanelli PC;Albers GW;Bello J;Derdeyn C;Hetts SW;Johnson MH;Kidwell C;Lev MH;Liebeskind DS;Rowley H;Schaefer PW;Sunshine JL;Zaharchuk G;Meltzer CC
通讯作者：
Meltzer CC
影响因子：
8.3
作者：
Jauch, Edward C.;Saver, Jeffrey L.;Yonas, Howard
通讯作者：
Yonas, Howard
影响因子：
9.9
作者：
Albers, GW
通讯作者：
Albers, GW
影响因子：
8.3
作者：
Johnston, Karen C.;Barrett, Kevin M.;Wagner, Douglas P.
通讯作者：
Wagner, Douglas P.
DOI：
10.1016/j.jstrokecerebrovasdis.2013.01.021
发表时间：
2013-05-01
影响因子：
2.5
作者：
Wendt, Matthias;Tuetuencue, Serdar;Nolte, Christian H.
通讯作者：
Nolte, Christian H.