Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium.
Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium.
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DOI：
10.1038/mp.2015.118
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发表时间：
2016-04
影响因子：
11
通讯作者：
Turner JA
中科院分区：
文献类型：
--
作者：
van Erp TG;Hibar DP;Rasmussen JM;Glahn DC;Pearlson GD;Andreassen OA;Agartz I;Westlye LT;Haukvik UK;Dale AM;Melle I;Hartberg CB;Gruber O;Kraemer B;Zilles D;Donohoe G;Kelly S;McDonald C;Morris DW;Cannon DM;Corvin A;Machielsen MW;Koenders L;de Haan L;Veltman DJ;Satterthwaite TD;Wolf DH;Gur RC;Gur RE;Potkin SG;Mathalon DH;Mueller BA;Preda A;Macciardi F;Ehrlich S;Walton E;Hass J;Calhoun VD;Bockholt HJ;Sponheim SR;Shoemaker JM;van Haren NE;Hulshoff Pol HE;Ophoff RA;Kahn RS;Roiz-Santiañez R;Crespo-Facorro B;Wang L;Alpert KI;Jönsson EG;Dimitrova R;Bois C;Whalley HC;McIntosh AM;Lawrie SM;Hashimoto R;Thompson PM;Turner JA
精神分裂症患者大脑结构异常的情况仍然没有完全了解，尽管使用大脑扫描进行了数十年的研究。为了验证前瞻性荟萃分析方法，分析多中心神经影像学数据，我们分析了2028例精神分裂症患者和2540例健康对照者的脑MRI扫描，在全球15个中心采用标准化方法进行评估。我们确定了区分患者和对照组的皮层下脑体积，并根据其效应大小对其进行了排名。与健康对照组相比，精神分裂症患者的海马（科恩d=-0.46）、杏仁核（d=-0.31）、丘脑（d =-0.31）、丘脑（d=-0.25）和颅内体积（d=-0.12）较小，苍白球（d= 0.21）和侧脑室体积（d= 0.37）较大。壳核和苍白球体积增大与病程呈正相关，海马缺损与未用药患者比例成比例。全球合作分析的脑成像数据支持的档案皮层下异常的精神分裂症，这是一致的，基于传统的荟萃分析方法。ENIGMA精神分裂症工作组的第一项研究验证了协作数据分析可以很容易地用于大脑表型和疾病，并鼓励分析和数据共享努力，以进一步了解严重的精神疾病。
The profile of brain structural abnormalities in schizophrenia is still not fully understood, despite decades of research using brain scans. To validate a prospective meta-analysis approach to analyzing multicenter neuroimaging data, we analyzed brain MRI scans from 2028 schizophrenia patients and 2540 healthy controls, assessed with standardized methods at 15 centers worldwide. We identified subcortical brain volumes that differentiated patients from controls, and ranked them according to their effect sizes. Compared with healthy controls, patients with schizophrenia had smaller hippocampus (Cohen’s d=− 0.46), amygdala (d=− 0.31), thalamus (d=− 0.31), accumbens (d=− 0.25) and intracranial volumes (d=− 0.12), as well as larger pallidum (d= 0.21) and lateral ventricle volumes (d= 0.37). Putamen and pallidum volume augmentations were positively associated with duration of illness and hippocampal deficits scaled with the proportion of unmedicated patients. Worldwide cooperative analyses of brain imaging data support a profile of subcortical abnormalities in schizophrenia, which is consistent with that based on traditional meta-analytic approaches. This first ENIGMA Schizophrenia Working Group study validates that collaborative data analyses can readily be used across brain phenotypes and disorders and encourages analysis and data sharing efforts to further our understanding of severe mental illness.
影响因子：
11
作者：
van Erp TG;Hibar DP;Rasmussen JM;Glahn DC;Pearlson GD;Andreassen OA;Agartz I;Westlye LT;Haukvik UK;Dale AM;Melle I;Hartberg CB;Gruber O;Kraemer B;Zilles D;Donohoe G;Kelly S;McDonald C;Morris DW;Cannon DM;Corvin A;Machielsen MW;Koenders L;de Haan L;Veltman DJ;Satterthwaite TD;Wolf DH;Gur RC;Gur RE;Potkin SG;Mathalon DH;Mueller BA;Preda A;Macciardi F;Ehrlich S;Walton E;Hass J;Calhoun VD;Bockholt HJ;Sponheim SR;Shoemaker JM;van Haren NE;Hulshoff Pol HE;Ophoff RA;Kahn RS;Roiz-Santiañez R;Crespo-Facorro B;Wang L;Alpert KI;Jönsson EG;Dimitrova R;Bois C;Whalley HC;McIntosh AM;Lawrie SM;Hashimoto R;Thompson PM;Turner JA
通讯作者：
Turner JA