Differential Reduction of IP-10 and C-Reactive Protein via Aerobic Exercise or Mindfulness-Based Stress-Reduction Training in a Large Randomized Controlled Trial.
Differential Reduction of IP-10 and C-Reactive Protein via Aerobic Exercise or Mindfulness-Based Stress-Reduction Training in a Large Randomized Controlled Trial.
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在大型随机对照试验中通过有氧运动或基于正念的减压训练差异性减少 IP-10 和 C 反应蛋白。
DOI：
10.1123/jsep.2018-0214
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发表时间：
2019
影响因子：
2.4
通讯作者：
Barrett,BruceP
中科院分区：
文献类型：
--
作者：
Meyer,JacobD;Hayney,MaryS;Coe,ChristopherL;Ninos,CameronL;Barrett,BruceP
锻炼和冥想可以通过减少全身炎症来改善健康和幸福感。在这项研究中，健康成年人（N= 413）被随机分为8周的有氧运动训练，匹配的正念减压训练，或等候名单控制。三种炎症相关的生物标志物（c反应蛋白、白细胞介素-6和干扰素- γ诱导蛋白-10）在干预前、干预后和17周后进行评估。组内分析发现，运动参与者在干预后和17周后血清干扰素- γ诱导蛋白-10降低，而仅在干预后17周，正念减压参与者的c反应蛋白较低。自我报告的身体活动或冥想练习量并不能预测生物标志物的变化。这项研究表明：(a)有氧运动训练可以降低干扰素γ诱导蛋白-10，这是一种与干扰素活性和疾病相关的趋化因子；(b)正念冥想训练可能对c反应蛋白（一种重要的炎症生物标志物）有延迟作用。这些发现强调了这些生活方式干预的健康促进作用背后可能存在多种不同的途径。
Exercise and meditation improve health and well-being, potentially through decreasing systemic inflammation. In this study, healthy adults (N= 413) were randomized to 8 weeks of training in aerobic exercise, matched mindfulness-based stress reduction, or wait-list control. Three inflammation-related biomarkers (C-reactive protein, interleukin-6, and interferon-gamma-inducible protein-10) were assessed preintervention, directly postintervention, and 17 weeks later. Within-group analyses found that exercise participants had decreased serum interferon-gamma-inducible protein-10 postintervention and 17 weeks later, whereas C-reactive protein was lower in mindfulness-based stress-reduction participants 17 weeks postintervention only. Self-reported physical activity or amount of meditation practice did not predict biomarker changes. This study suggests that (a) training in aerobic exercise can lower interferon-gamma-inducible protein-10, a chemokine associated with interferon activity and illness, and (b) training in mindfulness meditation may have a delayed effect on C-reactive protein, an important inflammatory biomarker. The findings highlight the likelihood of multiple, distinct pathways underlying the health-promoting effects of these lifestyle interventions.
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