The ESX-3 secretion system is necessary for iron and zinc homeostasis in Mycobacterium tuberculosis.
The ESX-3 secretion system is necessary for iron and zinc homeostasis in Mycobacterium tuberculosis.
复制标题
ESX-3分泌系统对于结核分枝杆菌中的铁和锌稳态是必需的。
DOI：
10.1371/journal.pone.0078351
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Manganelli R
中科院分区：
文献类型：
--
作者：
Serafini A;Pisu D;Palù G;Rodriguez GM;Manganelli R
ESX-3 is one of the five type VII secretion systems encoded by the Mycobacterium tuberculosis genome. We recently showed the essentiality of ESX-3 for M. tuberculosis viability and proposed its involvement in iron and zinc metabolism. In this study we confirmed the role of ESX-3 in iron uptake and its involvement in the adaptation to low zinc environment in M. tuberculosis. Moreover, we unveiled functional differences between the ESX-3 roles in M. tuberculosis and M. smegmatis showing that in the latter ESX-3 is only involved in the adaptation to iron and not to zinc restriction. Finally, we also showed that in M. tuberculosis this secretion system is essential for iron and zinc homeostasis not only in conditions in which the concentrations of these metals are limiting but also in metal sufficient conditions.
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影响因子：
3.1
作者：
Feltcher ME;Sullivan JT;Braunstein M
通讯作者：
Braunstein M
影响因子：
3.6
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Gold, B;Rodriguez, GM;Smith, I
通讯作者：
Smith, I
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3.7
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Di Luca M;Bottai D;Batoni G;Orgeur M;Aulicino A;Counoupas C;Campa M;Brosch R;Esin S
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30.3
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Botella H;Peyron P;Levillain F;Poincloux R;Poquet Y;Brandli I;Wang C;Tailleux L;Tilleul S;Charrière GM;Waddell SJ;Foti M;Lugo-Villarino G;Gao Q;Maridonneau-Parini I;Butcher PD;Castagnoli PR;Gicquel B;de Chastellier C;Neyrolles O
通讯作者：
Neyrolles O
影响因子：
6.7
作者：
Garces A;Atmakuri K;Chase MR;Woodworth JS;Krastins B;Rothchild AC;Ramsdell TL;Lopez MF;Behar SM;Sarracino DA;Fortune SM
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Fortune SM