Polymorphisms of interleukin-10 genes on the risk of ischemic stroke in a meta-analysis.
Polymorphisms of interleukin-10 genes on the risk of ischemic stroke in a meta-analysis.
复制标题
荟萃分析中白细胞介素 10 基因多态性与缺血性中风风险的关系。
DOI：
--
复制
发表时间：
2015-02
期刊：
影响因子：
--
通讯作者：
Xie, Xiang
中科院分区：
文献类型：
--
作者：
Liu, Fen;Chen, Bang-Dang;Gai, Min-Tao;Xie, Xiang
背景
先前的研究调查了白介素 10 (IL-10) 基因多态性与缺血性中风 (IS) 风险之间的关联。然而，结果并不一致。本研究的目的是通过荟萃分析方法阐明 IL-10 多态性与 IS 风险之间的关系。
方法
通过检索 PubMed 和万方数据库进行荟萃分析。根据 I(2) 值，通过固定或随机效应模型计算优势比 (OR) 和相应的 95% 置信区间 (95% CI) 以及效应大小。此次荟萃分析总共纳入了五项针对 IL10-1082G/A 的病例对照研究和四项针对 IL10-819C/T 的研究。
结果
联合分析表明，IL10-1082G/A 多态性与 IS 风险相关（A/A 与 G/G+G/A：OR = 1.82，95% CI = 1.21-2.74，P = 0.004；对于 A 等位基因与 G 等位基因：OR = 1.55，95% CI = 1.14-2.10，P = 0.006）。然而，在任何比较模型中，IL10-819C/T 多态性与 IS 之间均不存在显着相关性（C/C 与 T/C+T/T：OR = 0.96，95% CI = 0.69-1.36，P = 0.84；C 等位基因与 T 等位基因：OR = 1.00，95% CI = 0.83-1.21，P = 0.97）。
结论
我们的结果表明，IL-10-1082G/A 多态性（而非 IL10-819C/T 多态性）与 IS 风险相关。
BACKGROUND
Previous studies have investigated the associations between polymorphisms of interleukin-10 (IL-10) gene and risk of ischemic stroke (IS). However, the results were inconsistent. The aim of this study was to clarify the relationship between IL-10 polymorphisms and IS risk by a meta-analysis approach.
METHODS
The meta-analysis was performed by searching PubMed and Wanfang databases. Odds ratio (OR) and corresponding 95% confidence interval (95% CI) as well as effect size were calculated by a fixed or random-effect model according to the I(2) value. In total, five case-control studies for IL10-1082G/A and four studies for IL10-819C/T were included in this meta-analysis.
RESULTS
Combined analysis indicated that IL10-1082G/A polymorphism was associated with risk of IS (A/A vs. G/G+G/A: OR = 1.82, 95% CI = 1.21-2.74, P = 0.004; for A allele vs. G allele: OR = 1.55, 95% CI = 1.14-2.10, P = 0.006). However, there was no significant association between IL10-819C/T polymorphism and IS in any comparison model (C/C vs. T/C+T/T: OR = 0.96, 95% CI = 0.69-1.36, P = 0.84; C allele vs. T allele: OR = 1.00, 95% CI = 0.83-1.21, P = 0.97).
CONCLUSIONS
Our results indicated that IL-10-1082G/A polymorphism, but not IL10-819C/T polymorphism was associated with the risk of IS.
登录
查看更多内容
影响因子：
3.7
作者：
Hyun MH;Lee CH;Kang MH;Park BK;Lee YH
通讯作者：
Lee YH
DOI：
10.1016/0021-9681(79)90031-6
发表时间：
1979
期刊：
Journal of Chronic Diseases
影响因子：
--
作者：
R. Horwitz
通讯作者：
R. Horwitz
影响因子：
5.3
作者：
Bis, Joshua C.;Heckbert, Susan R.;Psaty, Bruce M.
通讯作者：
Psaty, Bruce M.
影响因子：
4.4
作者：
Harry Jerome
通讯作者：
Harry Jerome
影响因子：
1.5
作者：
Shehnaz Sultana;VENKATA K. Kolla;Yasovanthi Jeedigunta;Pranay K. Penagaluru;S. Joshi;P. U. Rani;P. Reddy
通讯作者：
Shehnaz Sultana;VENKATA K. Kolla;Yasovanthi Jeedigunta;Pranay K. Penagaluru;S. Joshi;P. U. Rani;P. Reddy